Department of Pediatrics/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education)/NHC Key Laboratory of Chronobiology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Neonatal Intensive Care Unit, Binzhou Medical University Hospital, Binzhou 256600, China.
Biomolecules. 2024 Sep 19;14(9):1175. doi: 10.3390/biom14091175.
Lactate, an important metabolic product, provides energy to neural cells during energy depletion or high demand and acts as a signaling molecule in the central nervous system. Recent studies revealed that lactate-mediated protein lactylation regulates gene transcription and influences cell fate, metabolic processes, inflammation, and immune responses. This review comprehensively examines the regulatory roles and mechanisms of lactylation in neurodevelopment, neuropsychiatric disorders, brain tumors, and cerebrovascular diseases. This analysis indicates that lactylation has multifaceted effects on central nervous system function and pathology, particularly in hypoxia-induced brain damage. Highlighting its potential as a novel therapeutic target, lactylation may play a significant role in treating neurological diseases. By summarizing current findings, this review aims to provide insights and guide future research and clinical strategies for central nervous system disorders.
乳酸是一种重要的代谢产物，在能量耗竭或需求高时为神经细胞提供能量，并在中枢神经系统中充当信号分子。最近的研究表明，乳酸介导的蛋白质乳酰化调节基因转录并影响细胞命运、代谢过程、炎症和免疫反应。本综述全面研究了乳酰化在神经发育、神经精神疾病、脑肿瘤和脑血管疾病中的调节作用和机制。该分析表明，乳酰化对中枢神经系统功能和病理学具有多方面的影响，特别是在缺氧诱导的脑损伤中。乳酰化作为一种新的治疗靶点，具有很大的潜力，可能在治疗神经疾病方面发挥重要作用。通过总结当前的研究结果，本综述旨在为中枢神经系统疾病的未来研究和临床策略提供见解和指导。
