重新审视阿尔茨海默病中的脑内皮细胞。 - Suppr

Suppr

超能文献

Revisiting cerebral endothelial cells in Alzheimer's disease.

作者信息

Hanafy Amira S

机构信息

Department of Neurosurgery, University Hospital Bonn, Bonn, Germany.

出版信息

Neural Regen Res. 2025 Oct 1;20(10):2911-2912. doi: 10.4103/NRR.NRR-D-24-00640. Epub 2024 Sep 24.

DOI:10.4103/NRR.NRR-D-24-00640

PMID:39610099

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11826457/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11826457/7ec14dee1494/NRR-20-2911-g001.jpg

相似文献

Revisiting cerebral endothelial cells in Alzheimer's disease.重新审视阿尔茨海默病中的脑内皮细胞。

Neural Regen Res. 2025 Oct 1;20(10):2911-2912. doi: 10.4103/NRR.NRR-D-24-00640. Epub 2024 Sep 24.

Post-mortem assessment of hypoperfusion of cerebral cortex in Alzheimer's disease and vascular dementia.阿尔茨海默病和血管性痴呆患者大脑皮层低灌注的死后评估。

Brain. 2015 Apr;138(Pt 4):1059-69. doi: 10.1093/brain/awv025. Epub 2015 Feb 16.

Insights into the transcriptomic heterogeneity of brain endothelial cells in normal aging and Alzheimer's disease.正常衰老和阿尔茨海默病中脑内皮细胞转录组异质性的见解

Neural Regen Res. 2026 Feb 1;21(2):569-576. doi: 10.4103/NRR.NRR-D-24-00695. Epub 2024 Dec 16.

Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer's disease.在阿尔茨海默病中，脑内皮细胞和平滑肌细胞的功能性连接钾通道活性受损。

Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2204581119. doi: 10.1073/pnas.2204581119. Epub 2022 Jun 21.

Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease.内皮细胞在不同脑区存在异质性，并在阿尔茨海默病中发生显著改变。

J Neurosci. 2023 Jun 14;43(24):4541-4557. doi: 10.1523/JNEUROSCI.0237-23.2023. Epub 2023 May 19.

Activation of Wnt/β-catenin pathway mitigates blood-brain barrier dysfunction in Alzheimer's disease.Wnt/β-连环蛋白通路的激活可减轻阿尔茨海默病的血脑屏障功能障碍。

Brain. 2022 Dec 19;145(12):4474-4488. doi: 10.1093/brain/awac236.

Impaired cerebral microvascular reactivity and endothelial SK channel activity in a streptozotocin-treated mouse model of Alzheimer's disease.链脲佐菌素处理的阿尔茨海默病小鼠模型中脑微血管反应性受损及内皮SK通道活性异常

J Alzheimers Dis. 2025 Feb;103(4):1112-1125. doi: 10.1177/13872877241309120. Epub 2025 Jan 10.

DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort.人脑皮层内皮细胞中的 DNA 损伤反应和衰老与阿尔茨海默病神经病理学进展的关系：基于人群的医疗研究委员会认知功能与衰老研究（MRC-CFAS）队列研究。

Neuropathol Appl Neurobiol. 2014 Dec;40(7):802-14. doi: 10.1111/nan.12156.

Evidence of endothelial dysfunction in the development of Alzheimer's disease: Is Alzheimer's a vascular disorder?阿尔茨海默病发展过程中内皮功能障碍的证据：阿尔茨海默病是一种血管疾病吗？

Am J Cardiovasc Dis. 2013 Nov 1;3(4):197-226.

VEGF Paradoxically Reduces Cerebral Blood Flow in Alzheimer's Disease Mice.血管内皮生长因子（VEGF）反常地减少阿尔茨海默病小鼠的脑血流量。

Neurosci Insights. 2022 Jul 4;17:26331055221109254. doi: 10.1177/26331055221109254. eCollection 2022.

本文引用的文献

Local perfusion of capillaries reveals disrupted beta-amyloid homeostasis at the blood-brain barrier in Tg2576 murine Alzheimer's model.局部灌注毛细血管揭示 Tg2576 阿尔茨海默病小鼠血脑屏障β淀粉样蛋白稳态失调。

Fluids Barriers CNS. 2023 Nov 22;20(1):85. doi: 10.1186/s12987-023-00492-7.

Subcellular analysis of blood-brain barrier function by micro-impalement of vessels in acute brain slices.在急性脑切片中通过微刺穿血管对血脑屏障功能进行亚细胞分析。

Nat Commun. 2023 Jan 30;14(1):481. doi: 10.1038/s41467-023-36070-6.

A human brain vascular atlas reveals diverse mediators of Alzheimer's risk.人脑血管图谱揭示了阿尔茨海默病风险的多种介质。

Nature. 2022 Mar;603(7903):885-892. doi: 10.1038/s41586-021-04369-3. Epub 2022 Feb 14.

Blood-brain barrier models: Rationale for selection.血脑屏障模型：选择的原理。

Adv Drug Deliv Rev. 2021 Sep;176:113859. doi: 10.1016/j.addr.2021.113859. Epub 2021 Jul 9.

Insight into the genetic etiology of Alzheimer's disease: A comprehensive review of the role of rare variants.深入了解阿尔茨海默病的遗传病因：对罕见变异作用的全面综述。

Alzheimers Dement (Amst). 2021 Feb 20;13(1):e12155. doi: 10.1002/dad2.12155. eCollection 2021.

Development of Azeliragon, an Oral Small Molecule Antagonist of the Receptor for Advanced Glycation Endproducts, for the Potential Slowing of Loss of Cognition in Mild Alzheimer's Disease.阿泽里龙的研发，一种晚期糖基化终产物受体的口服小分子拮抗剂，用于潜在减缓轻度阿尔茨海默病的认知能力下降。

J Prev Alzheimers Dis. 2018;5(2):149-154. doi: 10.14283/jpad.2018.18.

Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice.在小鼠中，膜转运蛋白 ABCC1 调节脑淀粉样β蛋白的稳定。

J Clin Invest. 2011 Oct;121(10):3924-31. doi: 10.1172/JCI57867. Epub 2011 Sep 1.

Differential effect of phenothiazines on MRP1 and P-glycoprotein activity.苯并二氮䓬类药物对 MRP1 和 P-糖蛋白活性的差异作用。

In Vivo. 2009 Nov-Dec;23(6):943-7.

Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice.灌注小鼠脑内血脑屏障通透性的测量方法：应用于野生型和阿尔茨海默病Tg2576小鼠中的β淀粉样肽

J Neurosci Methods. 2004 Sep 30;138(1-2):233-42. doi: 10.1016/j.jneumeth.2004.04.026.

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.晚期糖基化终末产物受体介导β淀粉样肽通过血脑屏障的转运并在脑内蓄积。

Nat Med. 2003 Jul;9(7):907-13. doi: 10.1038/nm890.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验