Reznikov Elizabeth A, Person Hannibal, Davis Emily, Zhao Yongdong, Otjen Jeffrey, Ambartsumyan Lusine, Len Mary, Scarlett Jarrad M
Division of Gastroenterology and Hepatology Seattle Children's Hospital Seattle Washington USA.
Department of Pediatrics University of Washington Seattle Washington USA.
JPGN Rep. 2024 Sep 10;5(4):514-518. doi: 10.1002/jpr3.12126. eCollection 2024 Nov.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that may involve any organ in the body. Inflammation of the bowel wall as a presenting symptom of SLE is uncommon and can lead to delays in diagnosis and treatment. Here, we discuss the case of an adolescent male who presented with weight loss, intermittent fevers, abdominal pain, vomiting, and diarrhea. Initially, inflammatory bowel disease (IBD) was suspected, but endoscopic evaluation did not support this diagnosis. A computed tomography scan of the abdomen revealed signs of serositis, concerning for an inflammatory process and the patient was referred to Rheumatology for further evaluation. Autoimmune serologies were obtained and combined with clinical findings confirmed a diagnosis of SLE. This case advances our understanding of SLE as a multisystemic disease and highlights an unusual presentation involving the gastrointestinal tract, which can mimic IBD and potentially delay the diagnosis and treatment process.
系统性红斑狼疮（SLE）是一种全身性自身免疫性疾病，可累及身体的任何器官。肠壁炎症作为SLE的首发症状并不常见，可能导致诊断和治疗延迟。在此，我们讨论一例青少年男性病例，该患者表现为体重减轻、间歇性发热、腹痛、呕吐和腹泻。最初怀疑为炎症性肠病（IBD），但内镜检查不支持这一诊断。腹部计算机断层扫描显示有浆膜炎迹象，提示存在炎症过程，患者被转诊至风湿病科进行进一步评估。进行了自身免疫血清学检查，并结合临床发现确诊为SLE。该病例增进了我们对SLE作为一种多系统疾病的理解，并突出了一种涉及胃肠道的不寻常表现，这种表现可能会模仿IBD，并可能延迟诊断和治疗过程。
