Bulut Sena Davran, Döndaş H Ali, Celebioglu Hasan Ufuk, Sansano José M, Döndaş Naciye Yaktubay
Department of Biotechnology, Institute of Natural and Applied Sciences, Çukurova University, Balcalı, Adana, 01330, Turkey.
Department of Biotechnology, Faculty of Science, Bartin University, Bartin, 74100, Turkey.
Probiotics Antimicrob Proteins. 2025 Jun 23. doi: 10.1007/s12602-025-10613-3.
The science of pharmacology investigates the effects of drugs on living organisms and vice versa. The frequency of side effects of some drugs used in traditional pharmacological treatment approaches and/or their inability to provide adequate treatment has led to the importance of new drug research and development (R&D) studies. Recently, due to the discovery that some diseases are associated with an imbalanced microbiota (dysbiosis), there has been a surge of interest in therapeutic approaches that can restore balance (biosis) to the microbiota. This review discusses the current status of the pharmabiotic potential of probiotics, prebiotics, synbiotics, paraprobiotics, postbiotics, metabiotics, next-generation probiotics, and fecal microbiota transplantation; describes their pharmacological functions from gastrointestinal disorders to neurodegenerative diseases; and also discusses the developments in pharmaceutical applications of probiotics and their derivatives.
药理学研究药物对生物体的作用，反之亦然。传统药物治疗方法中使用的某些药物的副作用发生率和/或它们无法提供充分治疗，这使得新药研发研究变得至关重要。最近，由于发现某些疾病与微生物群失衡（生态失调）有关，人们对能够恢复微生物群平衡（生态平衡）的治疗方法的兴趣激增。本综述讨论了益生菌、益生元、合生元、副益生菌、后生元、代谢物、下一代益生菌和粪便微生物群移植的药物生物学潜力的现状；描述了它们从胃肠道疾病到神经退行性疾病的药理功能；还讨论了益生菌及其衍生物在药物应用方面的进展。
