Sedgi Fatemeh Maleki, Hosseiniazar Mohammadreza Mohammad, Alizadeh Mohammad
Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Department of Nutrition, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
J Diabetes Metab Disord. 2024 Jun 19;23(2):1977-1987. doi: 10.1007/s40200-024-01453-z. eCollection 2024 Dec.
Clarified butter, contain harmful saturated and beneficial trans-fatty acids. Canola oil is a promising alternative to other oils for reducing saturated fat intake. This trial aimed to investigate the effects of replacing clarified butter with canola oil in patients with metabolic syndrome on various metabolic syndrome components, fatty liver index (FLI), and insulin resistance.
In this trial, 42 individuals with metabolic syndrome referred to the clinic in Imam Khomeini University Hospital in Urmia, Iran, were enrolled. The participants, who commonly consumed (3 to 8 serving per day) clarified butter, were instructed to follow a healthy diet and replace their consumption of clarified butter with an equivalent amount of canola oil for 3 months. To compare the differences of outcomes in the group, the paired samples T-test and cohen's d effect size were applied. To analyze the changes in dietary intakes and Metabolic equivalent of task (MET), repeated measures of ANOVA was used.
There was a significant decrease in fasting blood sugar (FBS) (< 0.001), triglyceride (TG) (0.003), and anthropometric measurements (< 0.001). Furthermore, significant reductions were observed in total cholesterol (TC) (< 0.001), low-density lipoprotein (LDL) (0.009), gamma-glutamyl transferase (GGT) levels (0.003), FLI (< 0.001), insulin levels (0.007), and homeostatic model assessment for insulin resistance (HOMA-IR) (0.002), and increase in quantitative insulin-sensitivity check index (QUICKI) (< 0.001). Unfavorably, there was a significant reduction in the high-density lipoprotein (HDL) (< 0.001).
The replacement of clarified butter with canola oil demonstrated potential benefits in improving metabolic syndrome.
The online version contains supplementary material available at 10.1007/s40200-024-01453-z.
澄清黄油含有有害的饱和脂肪酸和有益的反式脂肪酸。菜籽油有望成为减少饱和脂肪摄入的其他油类的替代品。本试验旨在研究代谢综合征患者用菜籽油替代澄清黄油对各种代谢综合征组分、脂肪肝指数（FLI）和胰岛素抵抗的影响。
在本试验中，招募了42名患有代谢综合征的个体，他们前往伊朗乌尔米亚伊玛目霍梅尼大学医院的诊所就诊。这些参与者通常每天食用（3至8份）澄清黄油，他们被要求遵循健康饮食，并在3个月内用等量的菜籽油替代他们食用的澄清黄油。为了比较该组结果的差异，应用了配对样本T检验和科恩d效应量。为了分析饮食摄入量和代谢当量（MET）的变化，使用了重复测量方差分析。
空腹血糖（FBS）（<0.001）、甘油三酯（TG）（0.003）和人体测量指标（<0.001）显著降低。此外，总胆固醇（TC）（<0.001）、低密度脂蛋白（LDL）（0.009）、γ-谷氨酰转移酶（GGT）水平（0.003）、FLI（<0.001）、胰岛素水平（0.007）和胰岛素抵抗稳态模型评估（HOMA-IR）（0.002）显著降低，定量胰岛素敏感性检查指数（QUICKI）升高（<0.001）。不利的是，高密度脂蛋白（HDL）显著降低（<0.001）。
用菜籽油替代澄清黄油在改善代谢综合征方面显示出潜在益处。
在线版本包含可在10.1007/s40200-024-01453-z获取的补充材料。
