Guerra Francesco Saverio, Palladino Nicola, Winzenrieth Renaud, Guglielmi Giuseppe
Department of Clinical and Experimental Medicine, Foggia University School of Medicine, Foggia, Italy.
3D-Sharper Medical, Barcelona, Spain.
J Diabetes Metab Disord. 2024 Aug 29;23(2):2191-2199. doi: 10.1007/s40200-024-01487-3. eCollection 2024 Dec.
Primary hyperparathyroidism (PHPT) is a disorder marked by chronic parathyroid hormone hypersecretion, which affects bone turnover and remodelling processes. With a loss of bone density and an increase in bone porosity, the cortical compartment is most severely impacted. The study's goal is to assess PHPT's effects on the volumetric bone mineral density (vBMD) of the femur's trabecular compartment as well as the vBMD and thickness of the cortical bone.
This is a retrospective case-control study, valuating age, biochemical doses, anthropometric measurements, and bone measurements. Between 2011 and 2016, 74 Caucasian Italian women and men with PHPT were sought out. Biochemical analyses were added to bone mineral density (BMD) values found in the lumbar spine and femoral neck. Proximal femur parameters such as cortical and trabecular volumetric (v) BMD, cortical thickness (CTh) and surface (s) BMD were analyzed by 3D-DXA software (3D-SHAPER Medical, Spain).
The findings showed a negative correlation between PHPT patients and controls, which was equally affecting the cortical and trabecular compartments. This correlation was especially evident in the areal BMD (aBMD) and vBMD measurements. Nonetheless, no appreciable correlation was found between the cortical level and the thickness of the cortical bone.
Parathormone (PHT) levels had an adverse effect on the cortical, trabecular volumetric density in this investigation, as was expected. Cortical thickness, however, is unaffected significantly. The literature and these findings are consistent.
原发性甲状旁腺功能亢进症（PHPT）是一种以慢性甲状旁腺激素分泌过多为特征的疾病，会影响骨转换和重塑过程。随着骨密度降低和骨孔隙率增加，皮质骨部分受到的影响最为严重。本研究的目的是评估PHPT对股骨小梁骨部分的体积骨密度（vBMD）以及皮质骨的vBMD和厚度的影响。
这是一项回顾性病例对照研究，评估年龄、生化指标、人体测量数据和骨测量数据。在2011年至2016年期间，寻找了74名患有PHPT的意大利白种人男女。将生化分析结果添加到腰椎和股骨颈的骨密度（BMD）值中。使用3D-DXA软件（西班牙3D-SHAPER Medical公司）分析股骨近端参数，如皮质骨和小梁骨的体积（v）BMD、皮质厚度（CTh）和表面（s）BMD。
研究结果显示PHPT患者与对照组之间存在负相关，对皮质骨和小梁骨部分均有影响。这种相关性在面积骨密度（aBMD）和vBMD测量中尤为明显。然而，在皮质骨水平与皮质骨厚度之间未发现明显相关性。
正如预期的那样，在本研究中甲状旁腺激素（PHT）水平对皮质骨和小梁骨体积密度有不利影响。然而，皮质厚度未受到显著影响。这些发现与文献一致。
