Chen Laurie, Harris Nathan, Sengupta Piali
Department of Biology, Brandeis University, Waltham, Massachusetts, United States.
Neuroscience Institute, Georgia State University, Atlanta, Georgia, United States.
MicroPubl Biol. 2024 Nov 13;2024. doi: 10.17912/micropub.biology.001382. eCollection 2024.
Temperature experience-regulated gene expression changes have been shown to underlie long-term adaptation of the response threshold of the AFD thermosensory neuron pair, and contribute to thermotaxis behavioral plasticity in . We previously showed that the SRTX-1 GPCR is expressed primarily in AFD and is localized to their sensory endings. Here we find that SRTX-1 levels are regulated by the animal's temperature experience. However, loss or overexpression of does not affect thermotaxis behaviors or examined temperature-evoked calcium responses in AFD. Our observations suggest that SRTX-1 may modulate AFD responses and behavior under defined temperature conditions, or in response to specific environmental stimuli.
温度体验调节的基因表达变化已被证明是AFD热感觉神经元对反应阈值长期适应的基础，并有助于秀丽隐杆线虫的趋温行为可塑性。我们之前表明，SRTX-1 G蛋白偶联受体主要在AFD中表达，并定位于它们的感觉末梢。在这里，我们发现SRTX-1的水平受动物温度体验的调节。然而，SRTX-1的缺失或过表达并不影响趋温行为或所检测的AFD中温度诱发的钙反应。我们的观察结果表明，SRTX-1可能在特定温度条件下或对特定环境刺激作出反应时调节AFD的反应和行为。
