Aoyang Institute of Cancer, Affiliated Aoyang Hospital of Jiangsu University, Suzhou, Jiangsu 215600, P.R. China.
Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.
Oncol Rep. 2025 Jan;53(1). doi: 10.3892/or.2024.8848. Epub 2024 Nov 29.
The health of individuals is seriously threatened by intestinal cancer, which includes pancreatic, colorectal, esophageal, gastric and gallbladder cancer. Most gastrointestinal cancers do not have typical and specific early symptoms, and lack specific and effective diagnostic markers and treatment methods. It is critical to understand the etiology of gastrointestinal cancer and develop more efficient methods of diagnosis and treatment. The cyclic GMP‑AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway serves a crucial role in the occurrence, progression and treatment of gastrointestinal cancer. The present review focuses on the latest progress regarding the role and mechanism of the cGAS/STING pathway in gastrointestinal cancer, and discusses treatment approaches and related applications based on the cGAS/STING signaling pathway. In order to improve the knowledge of the connection between the cGAS/STING pathway and gastrointestinal cancer, aid the diagnosis and treatment of gastrointestinal cancer, and lessen the burden on patients and society, the present review also discusses future research directions and existing challenges regarding cGAS/STING in the study of gastrointestinal cancer.
个体健康受到多种肠道癌症的严重威胁，包括胰腺癌、结直肠癌、食管癌、胃癌和胆囊癌。大多数胃肠道癌症没有典型和特异的早期症状，缺乏特异性和有效的诊断标志物及治疗方法。了解胃肠道癌症的病因并开发更有效的诊断和治疗方法至关重要。环鸟苷酸-腺苷酸合成酶（cGAS）/干扰素基因刺激物（STING）途径在胃肠道癌症的发生、发展和治疗中发挥着关键作用。本综述重点介绍了 cGAS/STING 通路在胃肠道癌症中的作用和机制的最新进展，并讨论了基于 cGAS/STING 信号通路的治疗方法和相关应用。为了提高对 cGAS/STING 通路与胃肠道癌症之间联系的认识，辅助胃肠道癌症的诊断和治疗，并减轻患者和社会的负担，本综述还讨论了 cGAS/STING 在胃肠道癌症研究中未来的研究方向和存在的挑战。
