一种源自人类肠道的菌株的基因组草图，该菌株可改善小鼠的结肠炎及与结肠炎相关的社交能力缺陷。
Draft genome of a human gut-derived sp. that ameliorates colitis and colitis-associated sociability deficits in mice.
作者信息
Murphy Michaela A, Brown D Garrett, Bell Rickesha S, Weis Allison M, Barrios Logan A, Stephens W Zac, Round June L
机构信息
Department of Pathology, Division of Microbiology and Immunology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA.
出版信息
Microbiol Resour Announc. 2025 Jan 16;14(1):e0072624. doi: 10.1128/mra.00726-24. Epub 2024 Nov 29.
Abstract
is a genus of anaerobic, gram-positive bacteria commonly found in mammalian gastrointestinal tracts. Yet, how variations among different strains can impact host health is poorly understood. We present a sp. genome isolated from human feces whose supplementation to mice can ameliorate colitis severity and associated sociability deficits.
摘要
是一种常见于哺乳动物胃肠道的厌氧革兰氏阳性菌属。然而，不同菌株之间的差异如何影响宿主健康却知之甚少。我们展示了一种从人类粪便中分离出的菌株基因组，将其补充给小鼠可改善结肠炎严重程度及相关的社交缺陷。
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