当抗抑郁药遇上肠道微生物群：影响与挑战 - Suppr | 超能文献

When antidepressants meet the gut microbiota: implications and challenges.

作者信息

Cussotto Sofia, Colle Romain, David Denis J, Corruble Emmanuelle

机构信息

Université Paris-Saclay, UVSQ, Centre de recherche en Epidémiologie et Santé des Populations (CESP), UMR 1018, CESP-Inserm, Team Moods, Faculté de Pharmacie, Bâtiment Henri Moissan, Orsay.

Université Paris-Saclay, Centre de recherche en Epidémiologie et Santé des Populations (CESP), MOODS UMR1018, CESP-Inserm, Team Moods, Faculté de Médecine, Le Kremin-Bicêtre.

出版信息

Int Clin Psychopharmacol. 2025 Jan 1;40(1):46-48. doi: 10.1097/YIC.0000000000000558. Epub 2024 Nov 27.

DOI:10.1097/YIC.0000000000000558

Abstract

摘要

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1

When antidepressants meet the gut microbiota: implications and challenges.当抗抑郁药遇上肠道微生物群：影响与挑战

Int Clin Psychopharmacol. 2025 Jan 1;40(1):46-48. doi: 10.1097/YIC.0000000000000558. Epub 2024 Nov 27.

2

Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive-like behavior.抗抑郁药会影响肠道微生物群，而 Ruminococcus flavefaciens 能够消除它们对抑郁样行为的影响。

Transl Psychiatry. 2019 Apr 9;9(1):133. doi: 10.1038/s41398-019-0466-x.

3

Antimicrobial activity of antidepressants on normal gut microbiota: Results of the study.抗抑郁药对正常肠道微生物群的抗菌活性：研究结果

Front Behav Neurosci. 2023 Mar 22;17:1132127. doi: 10.3389/fnbeh.2023.1132127. eCollection 2023.

4

Exploring the human gut microbiota targets in relation to the use of contemporary antidepressants.探索与使用当代抗抑郁药相关的人类肠道微生物菌群靶标。

J Affect Disord. 2024 Jan 1;344:473-484. doi: 10.1016/j.jad.2023.10.016. Epub 2023 Oct 18.

5

Pharmacomicrobiomics of Antidepressants in Depression: A Systematic Review.抑郁症中抗抑郁药的药物微生物组学：一项系统综述。

J Pers Med. 2023 Jun 30;13(7):1086. doi: 10.3390/jpm13071086.

6

Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness.抗抑郁药、抗菌药物还是两者皆有？抑郁症中的肠道微生物群失调以及抗抑郁药物抗菌作用对其疗效的潜在影响。

J Affect Disord. 2017 Jan 15;208:22-32. doi: 10.1016/j.jad.2016.09.012. Epub 2016 Sep 28.

7

Multi-omics reveal microbial determinants impacting the treatment outcome of antidepressants in major depressive disorder.多组学揭示了影响抗抑郁药治疗重度抑郁症治疗效果的微生物决定因素。

Microbiome. 2023 Aug 28;11(1):195. doi: 10.1186/s40168-023-01635-6.

8

Antidepressants fluoxetine and amitriptyline induce alterations in intestinal microbiota and gut microbiome function in rats exposed to chronic unpredictable mild stress.抗抑郁药氟西汀和阿米替林可诱导慢性不可预知轻度应激大鼠肠道微生物群及肠道微生物组功能的改变。

Transl Psychiatry. 2021 Feb 18;11(1):131. doi: 10.1038/s41398-021-01254-5.

9

A review of the antimicrobial side of antidepressants and its putative implications on the gut microbiome.抗抑郁药的抗菌作用及其对肠道微生物群的潜在影响综述。

Aust N Z J Psychiatry. 2019 Dec;53(12):1151-1166. doi: 10.1177/0004867419877954. Epub 2019 Sep 26.

10

The bidirectional interaction between antidepressants and the gut microbiota: are there implications for treatment response?抗抑郁药与肠道微生物群之间的双向相互作用：对治疗反应有何影响？

Int Clin Psychopharmacol. 2025 Jan 1;40(1):3-26. doi: 10.1097/YIC.0000000000000533. Epub 2024 Feb 6.

引用本文的文献

1

The Gut Microbiota Is Altered in Antidepressant-Free Depressed Patients and Is Associated With Depression Severity.未服用抗抑郁药的抑郁症患者肠道微生物群发生改变，且与抑郁严重程度相关。

J Neurochem. 2025 Jul;169(7):e70173. doi: 10.1111/jnc.70173.

2

Moving toward precision and personalized treatment strategies in psychiatry.迈向精神医学的精准和个性化治疗策略。

Int J Neuropsychopharmacol. 2025 May 9;28(5). doi: 10.1093/ijnp/pyaf025.

3

Anhedonia: Current and future treatments.快感缺失：当前与未来的治疗方法。

PCN Rep. 2025 Mar 23;4(1):e70088. doi: 10.1002/pcn5.70088. eCollection 2025 Mar.