Department of Ophthalmology, The Second Hospital of Dalian Medical University, Dalian, China.
Office of teaching affairs, Dalian Medical University, Dalian, China.
J Glob Health. 2024 Nov 29;14:04258. doi: 10.7189/jogh.14.04258.
This meta-analysis is to determine the risk of all-cause mortality and cardiovascular mortality of dual sensory impairment (DSI).
Relevant cohort studies were searched in Medline with PubMed, Cochrane Library, and EMBASE databases. The quality of the included studies was assessed based on the Newcastle-Ottawa Quality Assessment Scale (NOS). STATA software (USA) was used to conduct statistical analyses. To determine the source of heterogeneity, subgroup and sensitivity analyses were carried out. Funnel plots and the Egger's test were used for detecting publication bias.
This meta-analysis incorporated 12 cohort studies (1992-2024), containing 310 211 patients. Pooled analysis showed that DSI patients had a higher risk of all-cause mortality (hazard ratio (HR) = 1.442; 95% confidence interval (CI) = 1.303-1.596, I = 49.5%, P < 0.001), and cardiovascular mortality (HR = 1.832; 95% CI = 1.343-2.500, I = 0%, P < 0.001). Subgroup analyses on sex and territory type revealed that DSI were all associated with an increased risk of all-cause mortality.
This study shows that DSI is linked to higher risks of all-cause and cardiovascular mortality, suggesting that DSI should be regarded as an independent mortality risk factor. Physicians treating individuals with DSI should assess its impact on life expectancy.
The protocol was previously registered on the International Prospective Register of Systematic Reviews (PROSPERO) platform (CRD42024527256).
本荟萃分析旨在确定双重感觉障碍（DSI）患者全因死亡率和心血管死亡率的风险。
通过 Medline 联合 PubMed、Cochrane Library 和 EMBASE 数据库检索相关队列研究。根据 Newcastle-Ottawa 质量评估量表（NOS）评估纳入研究的质量。使用 STATA 软件（美国）进行统计分析。为了确定异质性的来源，进行了亚组和敏感性分析。漏斗图和 Egger 检验用于检测发表偏倚。
本荟萃分析纳入了 12 项队列研究（1992-2024 年），共包含 310211 名患者。汇总分析显示，DSI 患者全因死亡率风险更高（风险比（HR）=1.442；95%置信区间（CI）=1.303-1.596，I=49.5%，P<0.001），心血管死亡率风险更高（HR=1.832；95%CI=1.343-2.500，I=0%，P<0.001）。按性别和地域类型进行的亚组分析显示，DSI 均与全因死亡率风险增加相关。
本研究表明，DSI 与全因和心血管死亡率风险增加相关，提示 DSI 应被视为独立的死亡风险因素。治疗 DSI 患者的医生应评估其对预期寿命的影响。
该方案先前在国际前瞻性系统评价登记平台（PROSPERO）上注册（CRD42024527256）。
