Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Department of Medicine II, Medical Faculty Mannheim, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
Support Care Cancer. 2024 Nov 29;32(12):834. doi: 10.1007/s00520-024-09011-2.
Transferring adult cancer patients from the hospital to the home environment for home parenteral nutrition (HPN) can be challenging. There is limited real-world data on how those affected perceive this situation. Our aim was to assess the quality of life (QoL) on HPN and the benefits and burdens from the cancer patient's perspective.
This observational study from Germany examined the QoL on HPN on the basis of the Functional Assessment of Cancer Therapy - G questionnaire (FACT-G). The benefits and burdens of HPN were assessed using predefined questions and answers tailored to the situation of this patient group.
139 adults with advanced solid tumors in a palliative setting at 10 hospitals in Germany were eligible for the study. The follow-up was 12 weeks. At week 4, the Least-square (LS) mean (95% CI) change from baseline in the total FACT-G score was 0.9 (-2.4; 4.2) points, indicating QoL stability. HPN was associated with few complications, with a low rate of hospital readmission due to catheter-related issues (3.8%; n = 5). In the patient assessment of the benefits of HPN, the LS mean values at Week 4 ranged between 7.6 and 8.5 on a 10-point Likert scale. The most commonly perceived burden was "restricted mobility".
With thorough preparation for home parenteral nutrition, the transition from hospital to home care environment works well. QoL is largely maintained through HPN, and cancer patients perceive this situation as not or minimally burdensome alongside their underlying disease, although many patients found the limited mobility to be a burden.
NCT03425435 / Date of registration: February 01, 2018.
将成年癌症患者从医院转移到家庭环境中进行家庭肠外营养（HPN）可能具有挑战性。关于受影响者对此情况的看法，实际数据有限。我们的目的是评估 HPN 对生活质量（QoL）的影响，以及从癌症患者的角度来看 HPN 的益处和负担。
这项来自德国的观察性研究基于癌症治疗功能评估-一般问卷（FACT-G）评估 HPN 对 QoL 的影响。使用针对该患者群体情况量身定制的预设问题和答案来评估 HPN 的益处和负担。
德国 10 家医院的 139 名晚期实体瘤姑息治疗的成年人符合研究条件。随访时间为 12 周。第 4 周时，FACT-G 总分的最小二乘（LS）均值（95%CI）从基线的变化为 0.9（-2.4；4.2）点，表明 QoL 稳定。HPN 很少发生并发症，因导管相关问题导致的住院率也较低（3.8%；n=5）。在患者对 HPN 益处的评估中，第 4 周时的 LS 均值在 10 分制的 Likert 量表上介于 7.6 和 8.5 之间。最常被认为是负担的是“活动受限”。
通过对家庭肠外营养进行充分准备，从医院过渡到家庭护理环境的效果良好。通过 HPN 维持了大部分 QoL，癌症患者认为这种情况与他们的基础疾病相比没有或几乎没有负担，尽管许多患者认为活动受限是一种负担。
NCT03425435 / 注册日期：2018 年 2 月 1 日。
