Cardiff University School of Medicine, Cardiff, Wales, UK.
Department of Neurosurgery, University Hospital of Wales, Cardiff, Wales, UK.
Childs Nerv Syst. 2024 Nov 29;41(1):13. doi: 10.1007/s00381-024-06684-2.
This study presents a series of paediatric meningiomas and discusses aetiology, risk factors and outcomes with comparison to current literature.
This is a retrospective review of surgically treated paediatric meningiomas from three UK centres: the University Hospital of Wales, Alder Hey Children's Hospital and Royal Manchester Children's Hospital. Twenty-seven patients aged 16 and under at the time of their first procedure were identified over a 15-year period (1 January 2007 and 1 March 2023). Electronic medical records were used to collect data on age at presentation, sex, location of tumour(s), extent of resection, histology, WHO grade, complications, outcomes and associated conditions, notably neurofibromatosis type 2 (NF2).
Twenty-seven patients underwent 39 procedures. There were 13 males and 14 females. The median age was 13 years (range, 8 months to 16 years). Twenty-one (75%) were WHO grade 1, 6 (21%) were grade 2 and 1 (4%) was grade 3. Eight patients (30%) had confirmed NF2. Twelve patients (44%) were sporadic cases. Twenty-five percent and 50% were the recurrence rate in WHO grade 1 and 2 tumours, respectively.
The risk of grade 1 tumour recurrence was higher than within the adult population. This may be due to histological features of paediatric meningiomas differing from the adult population, and therefore, the WHO grading system may not be reflective of recurrence risk. Future molecular profiling and larger studies are required given the rarity of these cases.
本研究报告了一系列小儿脑膜瘤病例，并结合现有文献讨论了其病因、风险因素和结果。
这是对三家英国中心（威尔士大学医院、阿尔德希儿童医院和曼彻斯特皇家儿童医院）接受手术治疗的小儿脑膜瘤患者进行的回顾性研究。在 15 年期间（2007 年 1 月 1 日至 2023 年 3 月 1 日），共确定了 27 名 16 岁及以下的患者。通过电子病历收集了患者的年龄、性别、肿瘤位置、切除范围、组织学、世界卫生组织（WHO）分级、并发症、结果和相关疾病（尤其是神经纤维瘤病 2 型（NF2））的数据。
27 名患者共进行了 39 次手术。男性 13 例，女性 14 例。中位年龄为 13 岁（范围为 8 个月至 16 岁）。21 例（75%）为 WHO 1 级，6 例（21%）为 2 级，1 例（4%）为 3 级。8 例（30%）患者有明确的 NF2。12 例（44%）为散发性病例。1 级和 2 级肿瘤的复发率分别为 25%和 50%。
1 级肿瘤的复发风险高于成人人群。这可能是由于小儿脑膜瘤的组织学特征与成人不同，因此 WHO 分级系统可能不能反映复发风险。鉴于此类病例罕见，需要进行未来的分子谱分析和更大规模的研究。
