Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Department of Respiratory and Critical Care Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Sleep Breath. 2024 Nov 29;29(1):31. doi: 10.1007/s11325-024-03220-z.
The triglyceride glucose (TyG) index is a dependable indicator of insulin resistance (IR), serves as a valuable biomarker for identifying obstructive sleep apnea (OSA) and predicting its comorbidities. Both OSA and the TyG index are significantly related to the incidence and development of cardiovascular disease (CVD). We focus on investigating the relationship between the TyG index and the incidence of CVD risk in OSA.
The TyG index, homeostatic model assessment of IR (HOMA-IR) index, and polysomnography were assessed in 191 participants with OSA and without pre-existing CVD. To estimate the lifetime CVD risk, we employed the 'Prediction for Atherosclerotic CVD Risk in China' equation. The TyG index's association with CVD risk was scrutinized using multivariable logistic regression models, contrasting it with the HOMA-IR index. We compared the predictive power for high lifetime CVD risk of the TyG index and the HOMA-IR index using receiver-operating characteristic (ROC) curve analysis.
A total of 89 participants had high lifetime CVD risk. In fully adjusted model and additionally adjusted for HOMA-IR index, participants situated within the fifth quantile of the TyG index exhibited an increased lifetime CVD risk, with OR of 4.32 (95% CI, 1.19-15.67). The TyG index demonstrated significant predictive power for high lifetime CVD risk across varying severities of OSA and outperformed the HOMA-IR index, as evidenced by a larger area under the ROC curve.
The TyG index, independent of the HOMA-IR index and obesity, was linked to an increased lifetime CVD risk. In predicting cardiovascular outcomes, the TyG index could potentially outperform the HOMA-IR index among individuals with OSA.
甘油三酯-葡萄糖（TyG）指数是胰岛素抵抗（IR）的可靠指标，可作为识别阻塞性睡眠呼吸暂停（OSA）和预测其合并症的有价值的生物标志物。OSA 和 TyG 指数均与心血管疾病（CVD）的发生和发展密切相关。我们专注于研究 TyG 指数与 OSA 患者 CVD 风险发生率之间的关系。
对 191 名患有 OSA 且无既往 CVD 的患者进行 TyG 指数、稳态模型评估胰岛素抵抗（HOMA-IR）指数和多导睡眠图检查。采用“中国动脉粥样硬化性心血管疾病风险预测”方程评估终生 CVD 风险。使用多变量逻辑回归模型对比 HOMA-IR 指数，研究 TyG 指数与 CVD 风险的相关性。采用受试者工作特征（ROC）曲线分析比较 TyG 指数和 HOMA-IR 指数对高终生 CVD 风险的预测能力。
共有 89 名患者具有高终生 CVD 风险。在完全调整模型中，以及在进一步调整 HOMA-IR 指数后，TyG 指数五分位数值最高的参与者终生 CVD 风险增加，比值比（OR）为 4.32（95%可信区间，1.19-15.67）。TyG 指数在不同严重程度的 OSA 患者中均具有显著的高终生 CVD 风险预测能力，ROC 曲线下面积更大，优于 HOMA-IR 指数。
TyG 指数独立于 HOMA-IR 指数和肥胖，与终生 CVD 风险增加相关。在预测心血管结局方面，在 OSA 患者中，TyG 指数可能优于 HOMA-IR 指数。
