Li Min, Wan Yujing, Wei Ziyue, Lin Weihong
First Clinical School of Medicine (School of Information and Engineering), Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
BMC Gastroenterol. 2025 Apr 21;25(1):279. doi: 10.1186/s12876-025-03856-5.
Obstructive sleep apnoea (OSA), Non-alcoholic fatty liver disease (NAFLD) and insulin resistance (IR) are interlinked. The aim of our study was to investigate the predictive value of metabolic score for insulin resistance (METS-IR) and triglyceride-glucose(TyG) index in relation to OSA combined with NAFLD in physical examination population.
This is a retrospective observational study. 329 physical examiners who attended the healthcare centre of the First Affiliated Hospital of Wenzhou Medical University for polysomnography and abdominal ultrasonography (or CT abdominal scanning) from September 2021 to July 2024. Subjects were categorized into two groups according to the presence or absence of combined NAFLD. Logistic regression analysis and restricted cubic spline model (RCS) were used to evaluate the relationship between TyG index and METS-IR and NAFLD. The predictive value of TyG index and METS-IR for NAFLD was determined by receiver operating characteristic curves (ROC curves).
A total of 329 subjects were analyzed. The prevalence of NAFLD increased with increasing TyG index (P for trend < 0.001), and METS-IR showed an increasing-decreasing-increasing trend with NAFLD risk (P for trend < 0.001). RCS analysis showed a dose-response relationship between NAFLD risk and METS-IR (p = 0.012) and a linear relationship with the TyG index (p = 0.078), with a significant increase in the risk of NAFLD when the METS-IR exceeded a threshold of 47.47 (OR = 1). Compared with TyG index (AUC = 0.775, 95% CI: 0.711-0.828), METS-IR (AUC = 0.778, 95% CI: 0.716-0.836) had a higher predictive value for NAFLD in the OSA physical examination population.
In the OSA population, TyG index and METS-IR had predictive value for the development of NAFLD, with METS-IR being superior to TyG index.
阻塞性睡眠呼吸暂停（OSA）、非酒精性脂肪性肝病（NAFLD）和胰岛素抵抗（IR）相互关联。我们研究的目的是探讨代谢性胰岛素抵抗评分（METS-IR）和甘油三酯-葡萄糖（TyG）指数在体检人群中对OSA合并NAFLD的预测价值。
这是一项回顾性观察研究。2021年9月至2024年7月期间，329名在温州医科大学附属第一医院医疗保健中心接受多导睡眠图和腹部超声检查（或腹部CT扫描）的体检者纳入研究。根据是否合并NAFLD将受试者分为两组。采用逻辑回归分析和限制立方样条模型（RCS）评估TyG指数和METS-IR与NAFLD之间的关系。通过受试者工作特征曲线（ROC曲线）确定TyG指数和METS-IR对NAFLD的预测价值。
共分析了329名受试者。NAFLD的患病率随TyG指数升高而增加（趋势P<0.001），METS-IR随NAFLD风险呈先升高后降低再升高的趋势（趋势P<0.001）。RCS分析显示NAFLD风险与METS-IR之间存在剂量反应关系（p = 0.012），与TyG指数呈线性关系（p = 0.078），当METS-IR超过47.47的阈值时，NAFLD风险显著增加（OR = 1）。在OSA体检人群中，与TyG指数（AUC = 0.775，95%CI：0.711-0.828）相比，METS-IR（AUC = 0.778，95%CI：0.716-0.836）对NAFLD具有更高的预测价值。
在OSA人群中，TyG指数和METS-IR对NAFLD的发生具有预测价值，其中METS-IR优于TyG指数。
