Kaur Parminder, Sharma Pankaj, Bhatia Prateek, Singh Minu
Haematology-Oncology Unit, Department of Paediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Discov Oncol. 2024 Nov 29;15(1):729. doi: 10.1007/s12672-024-01618-5.
T-cell Acute Lymphoblastic Leukemia (T-ALL) is a highly aggressive form of ALL with at least 25% relapse rates. The high relapse rates are often linked to poor prognoses. More detailed studies for novel therapeutic targets for the treatment of T-ALL are required as the genetic and transcriptomic data currently available on T-ALL pathophysiology is insufficient. Long non-coding RNAs are emerging as important players in the regulation of tumour proliferation and metastasis. Studies on various cancers have revealed their potential as biomarkers and therapeutic targets in treatment. This review describes the characterization, biosynthesis, and role of long non-coding RNA in T-ALL and highlights their potential as next generation molecule in development of promising diagnostic, prognostic and/or therapeutic markers.
T细胞急性淋巴细胞白血病（T-ALL）是一种侵袭性很强的ALL形式，复发率至少为25%。高复发率往往与预后不良有关。由于目前关于T-ALL病理生理学的遗传和转录组数据不足，因此需要对治疗T-ALL的新型治疗靶点进行更详细的研究。长链非编码RNA正在成为肿瘤增殖和转移调控中的重要参与者。对各种癌症的研究揭示了它们作为治疗中的生物标志物和治疗靶点的潜力。这篇综述描述了长链非编码RNA在T-ALL中的特征、生物合成和作用，并强调了它们作为有前景的诊断、预后和/或治疗标志物开发中的下一代分子的潜力。
