[Effect of glucose concentration in bupivacaine solutions on the distribution of local anesthetics in cerebrospinal fluid during spinal anesthesia].

In two groups (ten patients each) catheter spinal anesthesia was performed with 3.0 ml bupivacaine hyperbaric (5% and 8% glucose was added). With special reference to the early phase following intrathecal injection, local anesthetic concentrations were measured by gas chromatography. A control group received 3.0 ml of isobaric bupivacaine intrathecally. With increasing specific gravity of these solutions, the CSF concentration of the local anesthetic decreased, which is interpreted as a consequence of inhomogeneous intrathecal distribution.