Hunan University of Medicine, Huaihua, China.
The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Medicine (Baltimore). 2024 Nov 29;103(48):e40729. doi: 10.1097/MD.0000000000040729.
Diabetic nephropathy (DN) is a common complication of diabetes, which is prone to develop into end-stage renal disease, and early diagnosis and treatment is the key to effective management of DN. Biomarkers have important clinical significance in the diagnosis and treatment of DN and have attracted extensive attention from researchers in recent years. The aim of this study was to visualize the field of biomarker research in DN through bibliometric analysis, to summarize the current status and predict future trends of this field, with a view to providing valuable insights for scholars and policy makers.
Literature search and data collection from Web of Science Core Collection. Calculations and visualizations were performed using Microsoft Excel, VOSviewer, Bibliometrix R-package, and CiteSpace.
We identified 1274 publications about biomarker research in DN from 1995 to November 01, 2023, with a steady increase in annual publications. China, Steno Diabetes Center in Denmark, and Frontiers in Endocrinology were the most productive country, institution, and journal, respectively; Mischak, Harald was both the most productive and highly cited author, and Kidney International was the most cited journal. The high frequency keywords were "albuminuria," "chronic kidney disease" and "expression." In addition, "macrophage," "fibrosis" and "omics" are potentially promising topics.
Our study comprehensively and visually summarized the important findings of global biomarker research in DN and revealed the structure, hotspots, and evolutionary trends in this field. It would inspire subsequent studies from a macroscopic perspective and provide a basis for rational allocation of resources and identification of collaborations among researchers.
糖尿病肾病（DN）是糖尿病的常见并发症，易发展为终末期肾病，早期诊断和治疗是有效管理 DN 的关键。生物标志物在 DN 的诊断和治疗中具有重要的临床意义，近年来引起了研究人员的广泛关注。本研究旨在通过文献计量分析可视化 DN 中生物标志物研究领域，总结该领域的现状和预测未来趋势，为学者和决策者提供有价值的见解。
从 Web of Science 核心合集进行文献检索和数据收集。使用 Microsoft Excel、VOSviewer、Bibliometrix R 包和 CiteSpace 进行计算和可视化。
我们从 1995 年至 2023 年 11 月 1 日确定了 1274 篇关于 DN 中生物标志物研究的出版物，年度出版物数量稳步增加。中国、丹麦的 Steno Diabetes Center 和 Frontiers in Endocrinology 分别是最具生产力的国家、机构和期刊；Mischak，Harald 既是最具生产力的作者也是引用率最高的作者，而 Kidney International 是被引用最多的期刊。高频关键词是“蛋白尿”、“慢性肾脏病”和“表达”。此外，“巨噬细胞”、“纤维化”和“组学”是潜在有前途的主题。
本研究全面而直观地总结了全球 DN 中生物标志物研究的重要发现，揭示了该领域的结构、热点和演变趋势。它将从宏观角度激发后续研究，并为研究人员之间的资源合理配置和合作提供依据。
