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高原性视网膜病变并视网膜出血:一例报告。

High-altitude retinopathy and retinal hemorrhage: A case report.

机构信息

Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing, China.

出版信息

Medicine (Baltimore). 2024 Nov 29;103(48):e40780. doi: 10.1097/MD.0000000000040780.

DOI:10.1097/MD.0000000000040780
PMID:39612408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11608720/
Abstract

RATIONALE

High-altitude retinopathy (HAR) is a retinal disorder caused by prolonged exposure to hypoxic environments at high altitudes, posing a significant threat to visual health and potentially leading to severe vision impairment. There have been limited references of HAR, with observations of its clinical manifestations and prognosis remaining insufficient. Some reports suggest that HAR may spontaneously resolve without eliciting any noticeable symptoms. This case focuses on the disease progression and follow-up results of a typical HAR patient, and a comprehensive ophthalmic examination was conducted, encompassing not only fundus examination and optic coherence tomography (OCT), but also fundus fluorescein angiography, Humphrey visual field examination, and electroretinogram.

PATIENT CONCERNS

A 41-year-old healthy Chinese man ascended from an altitude of 143 ft (43.5 m) to 13,780 ft (4200 m) rapidly. After living locally for 4 months, he developed decreased vision accompanied by visual field defects in his left eye.

DIAGNOSES

Ophthalmic examination revealed bilateral papilledema, peripapillary hemorrhage in his left eye, and retinal hemorrhage in the macular area of optic papilla. He was diagnosed with HAR.

INTERVENTIONS

Peribulbar injection of triamcinolone acetonide in the left eye, along with oral ginkgo biloba tablets to improve microcirculation, as well as mecobalamin tablets and vitamin B1 tablets for neural nutrition.

OUTCOMES

After 4 months, the patient's visual field defect decreased, and retinal hemorrhage was absorbed.

LESSONS

This case comprehensively reveals the clinical features of HAR, and highlights that HAR can lead to permanent visual function impairment if the individual fails to promptly leave the pathogenic environment.

摘要

背景

高原性视网膜病(HAR)是一种由长期暴露在高海拔缺氧环境中引起的视网膜疾病,对视力健康构成重大威胁,并可能导致严重的视力损害。有关 HAR 的参考资料有限,对其临床表现和预后的观察仍然不足。一些报告表明,HAR 可能会自行缓解,而不会引起任何明显的症状。本病例重点介绍了一位典型 HAR 患者的疾病进展和随访结果,进行了全面的眼科检查,不仅包括眼底检查和光学相干断层扫描(OCT),还包括眼底荧光血管造影、Humphrey 视野检查和视网膜电图。

患者关注

一名 41 岁健康的中国男性从海拔 143 英尺(43.5 米)迅速上升到 13780 英尺(4200 米)。在当地居住了 4 个月后,他出现了左眼视力下降,并伴有视野缺损。

诊断

眼科检查显示双侧视盘水肿,左眼视盘周围出血,黄斑区视网膜出血。他被诊断为 HAR。

干预措施

左眼球周注射曲安奈德,口服银杏叶提取物改善微循环,甲钴胺片和维生素 B1 片营养神经。

结果

4 个月后,患者的视野缺损减小,视网膜出血吸收。

教训

本病例全面揭示了 HAR 的临床特征,并强调如果个体未能及时离开致病环境,HAR 可能导致永久性视觉功能损害。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3820/11608720/121402d2bfe0/medi-103-e40780-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3820/11608720/22a9611bfefa/medi-103-e40780-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3820/11608720/471151eea627/medi-103-e40780-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3820/11608720/121402d2bfe0/medi-103-e40780-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3820/11608720/22a9611bfefa/medi-103-e40780-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3820/11608720/471151eea627/medi-103-e40780-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3820/11608720/121402d2bfe0/medi-103-e40780-g003.jpg

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High-altitude retinopathy and optical coherence tomography findings.高原视网膜病变与光学相干断层扫描结果
Semin Ophthalmol. 2010 Jan-Mar;25(1-2):13-5. doi: 10.3109/08820538.2010.481560.
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High-altitude retinopathy and altitude illness.高原视网膜病变与高原病。
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