来自巴西高流行地区的内脏利什曼病合并艾滋病病毒感染患者体内白细胞介素-6和白细胞介素-10细胞因子水平较高。
Higher levels of IL-6 and IL-10 cytokines in visceral leishmaniasis-HIV co-infected patients from Brazilian high endemic area.
作者信息
Costa Larissa Di Leo Nogueira, Cutrim Cristiane Michele Sampaio, de Almeida Santos Gustavo, de Lima Uiara Regina Silva, de Sousa Thayná Matos, do Nascimento Johnny Ramos, Silva Lucilene Amorim, Dall'Agnol Hivana Patricia Melo Barbosa, Dall'Agnol Leonardo Teixeira, Rodrigues Vandilson Pinheiro, de Azevedo Conceição de Maria Pedrozo Silva, Lima Mayara Ingrid Sousa
机构信息
Program in Health Sciences, Federal University of Maranhão, Brazil.
Program in Health and Environment, Federal University of Maranhão, Brazil.
出版信息
Cytokine. 2025 Jan;185:156812. doi: 10.1016/j.cyto.2024.156812. Epub 2024 Nov 28.
Visceral Leishmaniasis (VL) is an endemic disease in Latin America, and the clinical outcome worsens when a patient has HIV co-infection. In these patients, the immune response is complex and cytokines profile variable. We evaluate Th1/Th2/Th17 cytokine profile in VL/HIV patients from Brazilian high endemic area. In this cross-sectional study, the serological cytokines production was compared with clinical and epidemiological traits of the VL/HIV, VL and HIV patients. VL/HIV patients are predominantly male (89.2 %) with relapses in 35.5 % of the cases. There is higher serum levels of IL-6 (p = 0.006) and IL-10 (p < 0.001) in VL/HIV patients. Furthermore, there is a moderate or strong positive correlation in the serum levels of IL-6 and TNF-α (Rho = 0.635, p < 0.001), IL-10 and IFN-γ (Rho = 0.523, p < 0.001), IL-6 and IL-10 (Rho = 0.506, p < 0.001), IL-2 and IL-4 (Rho = 0.506, p < 0.001). Then, VL/HIV patients who died during VL treatment (p = 0.033), patients with oedema (p = 0.011), and patients with jaundice (p = 0.019) had statistically high levels of IL-6. In conclusion, VL/HIV patients have production or reduction of specific cytokines, highlights IL-6 and IL-10.
内脏利什曼病（VL）是拉丁美洲的一种地方病，当患者合并感染HIV时，临床结局会恶化。在这些患者中，免疫反应复杂，细胞因子谱也各不相同。我们评估了来自巴西高流行地区的VL/HIV患者的Th1/Th2/Th17细胞因子谱。在这项横断面研究中，将血清细胞因子的产生与VL/HIV患者、VL患者和HIV患者的临床及流行病学特征进行了比较。VL/HIV患者以男性为主（89.2%），35.5%的病例出现复发。VL/HIV患者的血清IL-6水平较高（p = 0.006），IL-10水平也较高（p < 0.001）。此外，IL-6与TNF-α的血清水平呈中度或强正相关（Rho = 0.635，p < 0.001），IL-10与IFN-γ呈正相关（Rho = 0.523，p < 0.001），IL-6与IL-10呈正相关（Rho = 0.506，p < 0.001），IL-2与IL-4呈正相关（Rho = 0.506，p < 0.001）。然后，在VL治疗期间死亡的VL/HIV患者（p = 0.033）、出现水肿的患者（p = 0.011）和出现黄疸的患者（p = 0.019）的IL-6水平在统计学上较高。总之，VL/HIV患者存在特定细胞因子的产生或减少，其中IL-6和IL-10较为突出。
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