非氨酯诱发的肺嗜酸性粒细胞增多症：一例报告

Febarbamate-induced pulmonary eosinophilia: a case report.

作者信息

Gali J M, Vilanova J L, Mayos M, Cornudella R, de las Heras P, Rodriguez Arias J M

出版信息

Respiration. 1986;49(3):231-4. doi: 10.1159/000194883.

DOI:10.1159/000194883

Abstract

Subacute pulmonary hypersensitivity to febarbamate is reported, manifested by peripheral eosinophilia, skin rash and pulmonary bilateral infiltrates. Bronchoalveolar lavage showed an increased eosinophil count, and transbronchial biopsy an intraalveolar and interstitial eosinophil infiltration. The reaction cleared on cessation of the drug, and a rechallenge test with febarbamate induced peripheral eosinophilia and skin rash.

摘要

据报道，存在对非氨酯的亚急性肺超敏反应，表现为外周血嗜酸性粒细胞增多、皮疹和双侧肺部浸润。支气管肺泡灌洗显示嗜酸性粒细胞计数增加，经支气管活检显示肺泡内和间质嗜酸性粒细胞浸润。停药后反应消退，再次使用非氨酯进行激发试验诱发了外周血嗜酸性粒细胞增多和皮疹。