Schatz P L, Mesologites D, Hyun J, Smith G J, Lahiri B
Saint Francis Hospital and Medical Center, Hartford, CT 06105.
Chest. 1989 Mar;95(3):685-7. doi: 10.1378/chest.95.3.685.
Captopril has not yet been included in the list of drugs causing hypersensitivity lung disease. We report a patient with hypertension, congestive heart failure, and chronic renal failure who, when rechallenged with captopril, developed upper lung field infiltrates associated with productive cough and striking peripheral eosinophilia. Gallium scan, transbronchial biopsy histologic findings, and direct immunofluorescent study were consistent with an immune-complex-mediated hypersensitivity reaction. There was no other etiology discovered for the patient's eosinophilia, nor was there evidence for an infectious etiology to explain his presentation.
卡托普利尚未被列入可引起过敏性肺病的药物清单。我们报告了一名患有高血压、充血性心力衰竭和慢性肾衰竭的患者，该患者再次使用卡托普利后，出现了上肺野浸润，并伴有咳痰和显著的外周血嗜酸性粒细胞增多。镓扫描、经支气管活检组织学检查结果以及直接免疫荧光研究均符合免疫复合物介导的超敏反应。未发现该患者嗜酸性粒细胞增多的其他病因，也没有证据表明存在感染性病因来解释其临床表现。
