Cardiology, University & Hospital, Fribourg, Switzerland.
Immunology and allergology, Geneva University Hospitals, Geneve, Switzerland.
BMJ Case Rep. 2024 Nov 28;17(11):e262018. doi: 10.1136/bcr-2024-262018.
A male patient in his early 60s was referred to the cardiology department for evaluation of a persistent apical ventricular thrombus following a myocardial infarction. Transthoracic echocardiography could not rule out the presence of an apical thrombus, leading to the intravenous administration of the contrast agent sulphur hexafluoride (SonoVue). The patient quickly exhibited signs of anaphylaxis accompanied by haemodynamic shock, resulting in cardiac arrest. He was successfully resuscitated with no significant secondary neurological impairment. According to the European Medicines Agency, anaphylactic reactions to the contrast agent sulphur hexafluoride (SonoVue) occur in approximately 1 in 10 000 cases. To our knowledge, this represents the first case of hypersensitivity to sulphur hexafluoride (SonoVue) confirmed by positive in vitro testing.
一位 60 岁出头的男性患者因心肌梗死后持续性心尖室壁血栓形成被转至心内科进行评估。经胸超声心动图不能排除心尖血栓的存在，因此给予六氟化硫（声诺维）静脉注射造影剂。患者很快出现过敏反应的迹象，并伴有血流动力学休克，导致心脏骤停。患者成功复苏，无明显继发性神经损伤。根据欧洲药品管理局的报告，使用六氟化硫（声诺维）造影剂发生过敏反应的概率约为每 10000 例 1 例。据我们所知，这是首例通过体外检测证实对六氟化硫（声诺维）过敏的病例。
