Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Nat Commun. 2024 Nov 29;15(1):10414. doi: 10.1038/s41467-024-54795-w.
Children born to mothers with polycystic ovary syndrome have a higher prevalence of cardiovascular risk factors and of subclinical cardiovascular disease, but the association between maternal polycystic ovary syndrome and cardiovascular disease in offspring is unclear. We conduct a register-based cohort study of 6 839 703 live singleton births from Denmark (1973-2016) and Sweden (1973-2014) and follow them for up to 48 years. Using Cox regression models, we find that offspring of mothers with polycystic ovary syndrome have a higher risk of overall cardiovascular diseases and of its specific subtypes, independently of comorbidities related to polycystic ovary syndrome. Cousin analyzes suggest that familial confounding does not explain our results. If our findings are replicated by future studies, children of women with polycystic ovary syndrome may benefit from early cardiovascular prevention efforts.
多囊卵巢综合征母亲所生的孩子患心血管风险因素和亚临床心血管疾病的患病率更高，但母亲多囊卵巢综合征与后代心血管疾病之间的关联尚不清楚。我们对来自丹麦（1973-2016 年）和瑞典（1973-2014 年）的 6839703 例活产单胎进行了基于登记的队列研究，并对其进行了长达 48 年的随访。使用 Cox 回归模型，我们发现多囊卵巢综合征母亲所生的孩子患心血管疾病和其特定亚型的风险更高，这与多囊卵巢综合征相关的合并症无关。表亲分析表明，家族性混杂并不能解释我们的结果。如果未来的研究能够复制我们的发现，那么多囊卵巢综合征女性的孩子可能会受益于早期心血管预防措施。
