Valentino Vincenzo, De Filippis Francesca, Marotta Roberto, Pasolli Edoardo, Ercolini Danilo
Department of Agricultural Sciences, University of Naples Federico II, Piazza Carlo di Borbone 1, Portici, 80055 Naples, Italy.
Department of Agricultural Sciences, University of Naples Federico II, Piazza Carlo di Borbone 1, Portici, 80055 Naples, Italy; Task Force on Microbiome Studies, University of Naples Federico II, Naples, Italy.
Cell Rep. 2024 Dec 24;43(12):115018. doi: 10.1016/j.celrep.2024.115018. Epub 2024 Nov 29.
The genus Ruminococcus is dominant in the human gut, but higher levels of some species, such as R. gnavus, R. torques, and R. bromii, have been linked to health or disease. In this study, we analyzed >9,000 Ruminococcus metagenome-assembled genomes (MAGs) reconstructed from >5,000 subjects and revealed significant links between the prevalence of some species/subspecies and geographic origin, age, lifestyle, and disease, with subspecies prevalent in specific subpopulations showing divergent metabolic potential. Furthermore, Ruminococcus species from Lachnospiraceae encoded for carbohydrate-active enzymes (CAZy) potentially involved in the metabolism of human N- and O-glycans, whereas those from Oscillospiraceae appear to be more adapted toward fiber metabolism. These new findings contribute to elucidating the potential functional role of Ruminococcus in specific lifestyles and diseases and to decipher the diversity and the adaptation of members of this genus to the human gut.
瘤胃球菌属在人类肠道中占主导地位，但某些物种（如迟缓瘤胃球菌、扭链瘤胃球菌和布氏瘤胃球菌）的较高水平与健康或疾病有关。在本研究中，我们分析了从5000多名受试者重建的9000多个瘤胃球菌宏基因组组装基因组（MAG），并揭示了某些物种/亚种的流行与地理起源、年龄、生活方式和疾病之间的显著联系，在特定亚群中流行的亚种表现出不同的代谢潜力。此外，来自毛螺菌科的瘤胃球菌物种编码了可能参与人类N-聚糖和O-聚糖代谢的碳水化合物活性酶（CAZy），而来自颤螺菌科的瘤胃球菌物种似乎更适应纤维代谢。这些新发现有助于阐明瘤胃球菌在特定生活方式和疾病中的潜在功能作用，并有助于解读该属成员对人类肠道的多样性和适应性。
