Dey Bhowmik Arpan, Shaw Pallab, Gopinatha Pillai Mohan Shankar, Rao Geeta, Dwivedi Shailendra Kumar Dhar
Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA; Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA.
Cancer Lett. 2024 Nov 29;611:217357. doi: 10.1016/j.canlet.2024.217357.
Ovarian cancer (OC) accounts for the highest mortality rates among all gynecologic malignancies. The high mortality of OC is often associated with delayed detection, prolonged latency, enhanced metastatic potential, acquired drug resistance, and frequent recurrence. This review comprehensively explores key aspects of OC, including cancer diagnosis, mechanisms of disease resistance, and the pivotal role of epigenetic regulation, particularly by microRNAs (miRs) in cancer progression. We highlight the intricate regulatory mechanisms governing miR expression within the context of OC and the current status of epigenetic advancement in the therapeutic development and clinical trial progression. Through network analysis we elucidate the regulatory interactions between dysregulated miRs in OC and their targets which are involved in different signaling pathways. By exploring these interconnected facets and critical analysis, we endeavor to provide a nuanced understanding of the molecular dynamics underlying OC, its detection and shedding light on potential avenues for miRs and epigenetics-based therapeutic intervention and management strategies.
卵巢癌（OC）在所有妇科恶性肿瘤中死亡率最高。OC的高死亡率通常与检测延迟、潜伏期延长、转移潜能增强、获得性耐药和频繁复发有关。本综述全面探讨了OC的关键方面，包括癌症诊断、疾病耐药机制以及表观遗传调控的关键作用，特别是微小RNA（miR）在癌症进展中的作用。我们强调了在OC背景下控制miR表达的复杂调控机制以及表观遗传学在治疗开发和临床试验进展中的现状。通过网络分析，我们阐明了OC中失调的miR与其参与不同信号通路的靶标之间的调控相互作用。通过探索这些相互关联的方面并进行批判性分析，我们努力对OC潜在的分子动力学、其检测提供细致入微的理解，并为基于miR和表观遗传学的治疗干预及管理策略的潜在途径提供线索。
