Association of the atherogenic index of plasma and modified triglyceride-glucose indices with digestive diseases among middle-aged and older population in China.

BACKGROUND

Previous studies have shown that metabolic imbalances contribute to digestive diseases. This study aimed to investigate the relationship of the atherogenic index of plasma (AIP) and modified triglyceride-glucose (TyG) indices with digestive diseases.

METHODS

We recruited participants aged 45 years or older from the China Health and Retirement Longitudinal Study (CHARLS, 2011 - 2020). The indices assessed included AIP, TyG, triacylglycerol glucose-waist circumference (TyG-WC), the triacylglycerol glucose-waist-to-height ratio (TyG-WHtR), and the triacylglycerol glucose-body mass index (TyG-BMI). We used logistic regression and restricted cubic spline (RCS) analyses to examine the associations between these indices and the incidence of digestive diseases.

RESULTS

A total of 4,453 participants were included in our analysis, 53.3% of whom were female, with an average age of 60 years. The incidence of digestive diseases in middle-aged and older adults was 6.18%. Compared with those in the lowest tertile group, the odds ratios (ORs) with 95% confidence intervals (CIs) for digestive diseases in the highest tertile for AIP, TyG, TyG-WC, TyG-WHtR, and TyG-BMI were 1.452 (1.07-1.972), 1.193 (0.873-1.631), 1.349 (1.044-1.743), 1.5 (1.089-2.068), and 1.312 (0.956-1.799), respectively. Sensitivity analyses confirmed the robustness of the correlations between these indices and digestive diseases.

CONCLUSION

Our study revealed that the AIP, TyG-WC, and TyG-WHtR were independently associated with the incidence of digestive diseases. These findings highlight the importance of considering and optimizing metabolic factors in management strategies for digestive diseases.