Su Zhou, Liang Jie, Liang Zhihai
Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, 530021, Guangxi Zhuang Autonomous Region, Nanning, China.
Department of Respiratory and Critical Care Medicine, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Sleep Breath. 2025 Sep 12;29(5):284. doi: 10.1007/s11325-025-03458-1.
This study aimed to explore the relationship between nighttime sleep duration trajectories and the risk of digestive diseases among middle-aged and older adults in China.
A total of 9521 participants aged 45 years or older from China Health and Retirement Longitudinal Study (CHARLS) were included in this longitudinal study. Nighttime sleep duration was analyzed using group-based trajectory model (GBTM) to identify distinct sleep duration trajectories. Binary logistic regression models were used to assess the associations between sleep duration trajectory groups and risks of digestive diseases and liver diseases. Data were analyzed using STATA and R.
The average age of 9,521 participants was 58.3 ± 8.5 years, and 53% were female. Baseline analysis indicated a negative correlation between sleep duration and digestive diseases risk. Over the seven-year follow-up period, GBTM identified four distinct sleep duration trajectories: short-descent trajectory (n = 1728, 18.1%), short-stable trajectory (n = 3824, 40.2%), short-ascent trajectory (n = 1476, 15.5%) and normal-stable trajectory (n = 2493, 26.2%). Compared to the normal-stable trajectory, the short-descent trajectory was significantly associated with higher risk of incident digestive diseases (OR = 2.063; 95% CI 1.724, 2.466; P < 0.001) and liver diseases (OR = 1.622; 95% CI 1.256, 2.094; P < 0.001). In stratified analysis, the results were consistent.
A short sleep duration trajectory was associated with an increased risk of incident digestive diseases among middle-aged and older Chinese adults. These findings highlight the importance of considering dynamic sleep duration patterns in strategies for managing digestive diseases.
本研究旨在探讨中国中老年人群夜间睡眠时长轨迹与消化系统疾病风险之间的关系。
本纵向研究纳入了来自中国健康与养老追踪调查（CHARLS）的9521名年龄在45岁及以上的参与者。使用基于群组的轨迹模型（GBTM）分析夜间睡眠时长，以识别不同的睡眠时长轨迹。采用二元逻辑回归模型评估睡眠时长轨迹组与消化系统疾病和肝脏疾病风险之间的关联。使用STATA和R软件进行数据分析。
9521名参与者的平均年龄为58.3±8.5岁，其中53%为女性。基线分析表明睡眠时长与消化系统疾病风险呈负相关。在七年的随访期内，GBTM识别出四种不同的睡眠时长轨迹：短下降轨迹（n = 1728，18.1%）、短稳定轨迹（n = 3824，40.2%）、短上升轨迹（n = 1476，15.5%）和正常稳定轨迹（n = 2493，26.2%）。与正常稳定轨迹相比，短下降轨迹与新发消化系统疾病（OR = 2.063；95%CI 1.724，2.466；P < 0.001）和肝脏疾病（OR = 1.622；95%CI 1.256，2.094；P < 0.001）的风险显著相关。分层分析结果一致。
睡眠时长较短的轨迹与中国中老年成年人新发消化系统疾病的风险增加有关。这些发现凸显了在消化系统疾病管理策略中考虑动态睡眠时长模式的重要性。
