Latifi-Pakdehi Tahereh, Khezrian Ali, Doosti-Irani Amin, Afshar Saeid, Mahdavinezhad Ali
Research Center for Molecular Medicine, Institute of Cancer, Avicenna Health Research Institute (AHRI), Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Discov Oncol. 2024 Dec 1;15(1):734. doi: 10.1007/s12672-024-01602-z.
Circular RNAs (circRNAs) has recently been considered a class of endogenous RNAs that form a continuous closed loop with an ability to cancer development. Due to its properties, circRNAs has promising potential to be considered as non-invasive cancer biomarkers. The present review comprehensively and systematically assessed the role of circRNAs as diagnostic markers in blood or tissue samples of colorectal cancer (CRC) patients. Articles published until September 2022 were searched across Scopus, Web of Science (WoS), and PubMed databases to screen and find suitable circRNAs as diagnostic markers in CRC, Based on inclusion and exclusion criteria, 55 articles were selected as the final included articles. The sample size of the patients group ranged from 12 to 212. Among the circRNAs investigated in this study, 47 circRNAs were increased in patients and probably act as oncogenes and activate the downstream pathways in the initiation and exacerbation of cancer; 28 circRNAs were decreased, which probably acted as tumor suppressors and their decrease played a role in the progression of CRC, indicating that the aberrant expression of circRNAs are involved in the promotion of CRC and may associated with its clinicopathological features. Many pathological processes of cancer are regulated by the altered expression of circRNAs through the regulation of different signaling pathways. According to the results of this study, while circRNAs demonstrates promise as a biomarker for CRC diagnosis, it is necessary to conduct evaluative studies on a larger scale in future.
环状RNA（circRNAs）最近被认为是一类内源性RNA，其形成连续闭环结构，具有影响癌症发展的能力。由于其特性，circRNAs有望成为非侵入性癌症生物标志物。本综述全面系统地评估了circRNAs作为诊断标志物在结直肠癌（CRC）患者血液或组织样本中的作用。检索了截至2022年9月在Scopus、科学网（WoS）和PubMed数据库上发表的文章，以筛选和寻找合适的circRNAs作为CRC的诊断标志物。根据纳入和排除标准，选择了55篇文章作为最终纳入文章。患者组的样本量从12到212不等。在本研究中所研究的circRNAs中，47种circRNAs在患者中表达增加，可能作为癌基因发挥作用，并在癌症的发生和恶化过程中激活下游通路；28种circRNAs表达降低，可能作为肿瘤抑制因子，其表达降低在CRC的进展中起作用，这表明circRNAs的异常表达参与了CRC的进展，可能与其临床病理特征相关。癌症的许多病理过程是由circRNAs通过调节不同信号通路的表达改变来调控的。根据本研究结果，虽然circRNAs有望作为CRC诊断的生物标志物，但未来有必要进行更大规模的评估研究。
