Zarp Jeff, Bruun Caroline Fussing, Christiansen Sille Tørring, Krogh Helle B, Kuchinke Oscar Vittorio, Bernsen Christoffer Leth, Jespersen Andreas Elleby, Bardram Jakob Eyvind, Kessing Lars Vedel, Miskowiak Kamilla Woznica
Copenhagen Affective Disorder Research Centre (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.
Neurocognition and Emotion in Affective Disorders (NEAD) Centre, Psychiatric Centre Copenhagen, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.
Nord J Psychiatry. 2025 Jan;79(1):52-61. doi: 10.1080/08039488.2024.2434601. Epub 2024 Dec 1.
Cognitive impairments are prevalent during remission in bipolar disorder (BD), but existing cognitive screening tools are time- and resource-intensive. Digital, web-based options can facilitate detection and monitoring of these impairments across clinical and research settings.
This cross-sectional study investigated psychometric properties of the Internet-based Cognitive Assessment Tool (ICAT) when self-administered in home-based settings. Newly diagnosed, remitted outpatients with BD and healthy controls (HC) underwent cognitive testing with the standard paper-pencil tool Screen for Cognitive Impairment in Psychiatry (SCIP) in-clinic and ICAT at-home as part of baseline assessments for an intervention trial (ClinicalTrials ID: 2021-000862-14).
Data were analyzed for 31 BD patients and 29 HC. We demonstrated a strong positive correlation between at-home ICAT and in-clinic SCIP total scores within patients with BD ((29) = 0.66, < .001), which survived subsyndromal mood symptoms adjustment (partial (25) = 0.67, < .001), indicating adequate concurrent validity. There was a moderate positive correlation between ICAT and SCIP total scores across the entire sample ((54) = 0.56, < .001) and between subtest scores ( = 0.29-0.61, s ≤ .03), except the executive functions tasks ( = .1). BD patients exhibited no impaired performance compared to HC on ICAT or SCIP (s ≥ .08).
ICAT is a valid and feasible online tool for remote cognitive screening in remitted patients with BD. Web-based screening constitutes an accessible and efficient approach for implementing systematic cognitive screening in BD.
双相情感障碍（BD）缓解期认知障碍普遍存在，但现有的认知筛查工具耗时且资源密集。基于网络的数字选项有助于在临床和研究环境中检测和监测这些障碍。
这项横断面研究调查了基于互联网的认知评估工具（ICAT）在家庭环境中自行使用时的心理测量特性。作为一项干预试验（临床试验标识符：2021-000862-14）基线评估的一部分，新诊断的缓解期BD门诊患者和健康对照（HC）在诊所接受了标准纸笔工具《精神病学认知障碍筛查量表》（SCIP）的认知测试，并在家中接受了ICAT测试。
对31名BD患者和29名HC的数据进行了分析。我们证明，BD患者在家中ICAT总分与诊所SCIP总分之间存在强正相关（(29) = 0.66， <.001），在调整亚综合征情绪症状后仍然显著（偏相关(25) = 0.67， <.001），表明具有足够的同时效度。在整个样本中，ICAT与SCIP总分之间存在中度正相关（(54) = 0.56， <.001），各子测试分数之间也存在正相关（ = 0.29 - 0.61，s ≤.03），除执行功能任务外（ = 0.1）。与HC相比，BD患者在ICAT或SCIP上的表现没有受损（s ≥.08）。
ICAT是一种用于BD缓解期患者远程认知筛查的有效且可行的在线工具。基于网络的筛查是在BD中实施系统认知筛查的一种便捷高效的方法。
