Chang Junfang, Wu Weijun, Wu Ranran, Guo Zhiyong, Wang Sui, Mao Jie
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, PR China.
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, PR China.
Biomater Adv. 2025 Mar;168:214126. doi: 10.1016/j.bioadv.2024.214126. Epub 2024 Nov 28.
The flexible surface and chemical compatibility of hydrogels render them particularly appealing for research and development in antibacterial materials. However, designing tough hydrogels with multiple antibacterial mechanisms simultaneously remains a challenge. Inspired by the human skin, a hydrogel with bacterial antifouling, detection, and inactivation functions has been prepared using zwitterionic [2-(methylacrylyl) ethyl] dimethyl-(3-propyl sulfonate) ammonium hydroxide (SBMA) as the matrix and cadmium telluride quantum dots functionalised with cysteamine (CA-CdTe QDs) as the filler through micelle copolymerisation technology, achieving the integration of multiple antimicrobial mechanisms. The experimental analysis demonstrated that the SBMA/CA-CdTe/Micelle (SCM) hydrogel exhibited antibacterial activity against both Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus), proving its excellent broad-spectrum antibacterial properties. Introducing micelles imparts excellent hydrophilicity, stability, and mechanical properties to the SCM hydrogel. Moreover, the SCM hydrogels possess significant self-adhesive properties, enabling them to function as biomimetic skin that tightly adheres to target surfaces, protecting them from bacterial contamination. In addition, the SCM hydrogel biomimetic skin exhibits good electrical conductivity and biocompatibility, capable of converting the motion amplitude of human activity into stable electrical signals, suggesting potential for human motion sensing applications. Overall, the SCM hydrogel biomimetic skin designed in this work, as a multifunctional antibacterial platform, effectively reduces bacterial contamination and holds significant application potential in healthcare and life sciences.
水凝胶的柔性表面和化学兼容性使其在抗菌材料的研发中极具吸引力。然而，同时设计具有多种抗菌机制的坚韧水凝胶仍然是一项挑战。受人类皮肤启发，通过胶束共聚技术，以两性离子型[2-(甲基丙烯酰基)乙基]二甲基-(3-丙基磺酸盐)氢氧化铵（SBMA）为基质、以半胱胺功能化的碲化镉量子点（CA-CdTe QDs）为填料，制备了一种具有细菌防污、检测和灭活功能的水凝胶，实现了多种抗菌机制的整合。实验分析表明，SBMA/CA-CdTe/胶束（SCM）水凝胶对革兰氏阴性菌（大肠杆菌）和革兰氏阳性菌（金黄色葡萄球菌）均表现出抗菌活性，证明了其优异的广谱抗菌性能。引入胶束赋予了SCM水凝胶优异的亲水性、稳定性和机械性能。此外，SCM水凝胶具有显著的自粘性能，使其能够作为仿生皮肤紧密粘附在目标表面，保护其免受细菌污染。此外，SCM水凝胶仿生皮肤具有良好的导电性和生物相容性，能够将人体活动的运动幅度转化为稳定的电信号，显示出在人体运动传感应用中的潜力。总体而言，本文设计的SCM水凝胶仿生皮肤作为一种多功能抗菌平台，有效减少了细菌污染，在医疗保健和生命科学领域具有重要的应用潜力。
