[Chronobiological approach to the diagnosis and therapy of cardiovascular diseases].

Some aspects of chronodiagnosis and chronotherapy of cardiovascular diseases were described. To reveal circadian cycles each examined person was observed for 3-5 days, the indices studied being measured every 4 h. The evaluation of a rhythm period was done using the dispersion analysis for the detection of non-sinusiodal rhythms and the approximation method for the detection of sinusoidal rhythms with a preset period (the cosignor analysis) and an unknown period (the least square method combined with the iteration method). Opportunities for the detection of changes or disorders of the time structure of examined function and approaches to chronotherapy were studied on clinical material.