Harteveld Lisette M, van Leeuwen Lisanne M, Euser Sjoerd M, Smit Lucy J, Vollebregt Karlijn C, Bogaert Debby, van Houten Marlies A
Department of Paediatrics and of Vaccine, Infection and Immunology, Spaarne Gasthuis Hospital, Haarlem, the Netherlands.
Regional Public Health Laboratory Kennemerland, Haarlem, the Netherlands.
Vaccine. 2025 Jan 12;44:126541. doi: 10.1016/j.vaccine.2024.126541. Epub 2024 Nov 30.
Respiratory syncytial virus (RSV) is a leading cause of infant respiratory disease. Recent approval of preventive measures like a long-acting monoclonal antibody and a maternal vaccine signals a potential shift in early-life RSV infection control. However, success hinges on acceptance.
We conducted a cross-sectional survey among pregnant women and partners in the Netherlands, recruited via healthcare professionals, social media platforms, and the 9-Months Fair. The survey assessed willingness and motivation for maternal RSV vaccination and neonatal RSV immunization, including strategy preferences and informational needs.
In total 1001 pregnant women (mean age: 31.1 years) and their partners (mean age: 33.2 years) completed the survey. On average, they were 24 weeks pregnant at the time, and 54.6 % had no other children yet. The majority was Dutch-born (95.2 % of women); with 68.3 % of women having completed higher education and with overall strong pro-vaccination attitudes (93.9 % of partners intended to vaccinate their expected newborn). The overall acceptability to vaccination and immunization was high, with 87 % of respondents indicating they would (likely) accept both strategies. A positive attitude towards both methods was associated with previous experience with severity of RSV, intention to vaccinate the newborn and parental vaccination status during childhood and current pregnancy. When the choice was given, the majority of participants, in particular those with children and the intention to breastfeed, favoured maternal vaccination over passive immunization of infants (75.3 % of the pregnant and 71.6 % of the partners). A majority of the respondents cited optimal protection for the child and knowledge of RSV as important factors for accepting RSV prophylaxis.
While most participants would accept both strategies for RSV protection of their infant, a majority, especially those with other children, favoured maternal vaccination, due to concerns about infant safety and awareness of RSV severity.
呼吸道合胞病毒（RSV）是婴儿呼吸道疾病的主要病因。近期长效单克隆抗体和母体疫苗等预防措施的获批预示着早期RSV感染控制可能出现转变。然而，成功与否取决于接受程度。
我们在荷兰的孕妇及其伴侣中开展了一项横断面调查，通过医疗保健专业人员、社交媒体平台和9个月博览会招募参与者。该调查评估了母体RSV疫苗接种和新生儿RSV免疫的意愿及动机，包括策略偏好和信息需求。
共有1001名孕妇（平均年龄：31.1岁）及其伴侣（平均年龄：33.2岁）完成了调查。当时她们平均怀孕24周，54.6%尚无其他子女。大多数人出生在荷兰（95.2%的女性）；68.3%的女性完成了高等教育，总体上对疫苗接种态度积极（93.9%的伴侣打算为预期出生的新生儿接种疫苗）。疫苗接种和免疫的总体接受度较高，87%的受访者表示他们（可能）会接受这两种策略。对这两种方法的积极态度与既往RSV严重程度经历、为新生儿接种疫苗的意愿以及童年和当前孕期的父母疫苗接种状况有关。当提供选择时，大多数参与者，尤其是有子女且打算母乳喂养的参与者，更倾向于母体疫苗接种而非婴儿被动免疫（75.3%的孕妇和71.6%的伴侣）。大多数受访者认为对儿童的最佳保护和对RSV的了解是接受RSV预防措施的重要因素。
虽然大多数参与者会接受保护婴儿免受RSV感染的两种策略，但由于对婴儿安全的担忧和对RSV严重程度的认识，大多数人，尤其是有其他子女的人，更倾向于母体疫苗接种。
