Mgenge Lungelo, Saha Chandan, Kumari Pooja, Ghosh Sarit K, Singh Harishchandra, Mallick Kaushik
Department of Chemical Sciences, University of Johannesburg, P.O. Box: 524, Auckland Park, 2006, South Africa.
Department of Chemical Sciences, University of Johannesburg, P.O. Box: 524, Auckland Park, 2006, South Africa.
Anal Biochem. 2025 Mar;698:115726. doi: 10.1016/j.ab.2024.115726. Epub 2024 Nov 29.
Dopamine, one of the most important neurotransmitters, plays a crucial role in the functions of human metabolism, as well as the cardiovascular, central nervous and hormonal systems. This study focuses on the synthesis of nanostructured silver chromate and their application in dopamine sensing. The nanoparticles were synthesized using a complexation-mediated route using aminosalicylic acid as a stabilizer, resulting in uniform particles ranging from 3 to 15 nm in size. The synthesized silver chromate was characterized using X-ray diffraction, transmission electron microscopy and X-ray photoelectron spectroscopy techniques. Electrochemical studies revealed that the silver chromate exhibit excellent catalytic activity for the detection of dopamine. The electroanalysis provided the selective recognition of dopamine with the limit of detection of 1.05 μM and sensitivity of 2.68 μA μM cm in a linear range of 5-45 μM. Additionally, a portable, IoT (internet of things)-integrated sensor based on the synthesized silver chromate was developed using Arduino Uno R4 Wi-Fi module, enabling real-time monitoring of dopamine with data transmission to a cloud platform.
多巴胺是最重要的神经递质之一，在人体新陈代谢以及心血管、中枢神经和内分泌系统的功能中发挥着关键作用。本研究聚焦于纳米结构铬酸银的合成及其在多巴胺传感中的应用。通过以氨基水杨酸作为稳定剂的络合介导路线合成了纳米颗粒，得到了尺寸在3至15纳米之间的均匀颗粒。使用X射线衍射、透射电子显微镜和X射线光电子能谱技术对合成的铬酸银进行了表征。电化学研究表明，铬酸银对多巴胺的检测表现出优异的催化活性。电分析在5至45微摩尔的线性范围内实现了对多巴胺的选择性识别，检测限为1.05微摩尔，灵敏度为2.68微安/微摩尔/平方厘米。此外，利用Arduino Uno R4 Wi-Fi模块开发了一种基于合成铬酸银的便携式物联网集成传感器，能够对多巴胺进行实时监测，并将数据传输至云平台。
