补肾壮骨疗法治疗肾虚型类风湿关节炎的临床疗效和安全性的网状 Meta 分析。
Network Meta-analysis of the clinical efficacy and safety of kidney-tonifying and bone-strengthening therapies for the treatment of rheumatoid arthritis with kidney deficiency type.
机构信息
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
2 Department of Traditional Chinese Medicine Rheumatology, China-Japan Friendship Hospital, Beijing 100029, China.
出版信息
J Tradit Chin Med. 2024 Dec;44(6):1067-1081. doi: 10.19852/j.cnki.jtcm.20240927.002.
OBJECTIVE
To compare the efficacy and safety of different Traditional Chinese Medicine (TCM)-based kidney-tonifying and bone-strengthening therapies for rheumatoid arthritis (RA).
METHODS
The current Bayesian network Meta-analysis compared different TCM-based kidney-tonifying and bone-strengthening therapies for RA. Eight electronic databases and two trial registration platforms were searched. RevMan 5.4 and Stata 16 software were employed.
RESULTS
A total of 42 studies involving 3779 cases were included. The results showed that the most effective intervention for improving efficacy was Wanbi decoction; Bushen Quhan Zhiwang decoction was superior in reducing the incidence of adverse reactions; and Qiwei Tongbi oral liquid effectively reduced C-reactive protein and erythrocyte sedimentation rate levels.
CONCLUSION
Combining TCMs with conventional Western Medicine can improve the clinical efficacy of RA treatments, reduce inflammatory indexes, and result in a higher safety profile. However, this conclusion needs to be verified by more high-quality randomized controlled trials.
目的
比较不同补肾壮骨的中医药疗法治疗类风湿关节炎（RA）的疗效和安全性。
方法
本贝叶斯网状 Meta 分析比较了不同补肾壮骨的中医药疗法治疗 RA 的疗效。检索了 8 个电子数据库和 2 个试验注册平台。使用 RevMan 5.4 和 Stata 16 软件。
结果
共纳入 42 项研究，涉及 3779 例患者。结果表明，改善疗效最有效的干预措施是万痹汤；补肾祛寒治尫痹汤在降低不良反应发生率方面更具优势；而芪卫通痹口服液能有效降低 C 反应蛋白和红细胞沉降率水平。
结论
中西药结合治疗 RA 能提高临床疗效，降低炎症指标，安全性更高。但该结论尚需更多高质量的随机对照试验验证。
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