Huizinga W K, Chadwick S J, Jialal I, Desai R K
Trop Geogr Med. 1986 Mar;38(1):96-100.
Urgent thyroidectomy for giant multinodular goitre causing airway obstruction was necessary in the mater familias of a family with a high prevalence of non-endemic goitre. Post operative complications are briefly discussed. Family screening revealed a 100% incidence of nodular goitre in eight first generation descendants with hyperthyroidism in one. A euthyroid pattern was found in 6 of these, as well as in 5 of 19 second generation descendants tested. In two of the first generation descendants dyshormonogenesis was excluded as an aetiological factor by the perchlorate discharge test.
对于一个非地方性甲状腺肿高发家族的女家长，因巨大结节性甲状腺肿导致气道阻塞而进行紧急甲状腺切除术是必要的。文中简要讨论了术后并发症。家族筛查显示，8名第一代后代中结节性甲状腺肿的发病率为100%，其中1人患有甲状腺功能亢进症。在这些第一代后代中有6人以及在接受检测的19名第二代后代中有5人呈现甲状腺功能正常的状态。通过高氯酸盐释放试验，排除了第一代后代中的2人存在激素合成障碍作为病因学因素的可能性。
