Zhang Xiaomei, Wang Shi, Xu Sanping, Min Rui, Ling Yan, Sun Shiran, Gong Rui
Health Management Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People's Republic of China.
School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Nov 25;17:4397-4406. doi: 10.2147/DMSO.S482638. eCollection 2024.
This study aimed to investigate the risk factors and predictors of non-obese fatty liver disease in the Chinese population.
A total of 6,014 adults who underwent physical examinations at Union Hospital of Huazhong University of Science and Technology from March 2019 to March 2023 were included in this study. Fatty liver disease was diagnosed based on at least two of the following criteria: diffuse echo patterns relative to the liver, spleen, and kidney; ultrasonic beam attenuation; and poor intrahepatic visual details. The associations between non-obese fatty liver and gender, age, total bilirubin(TBIL), direct bilirubin(DBIL), alanine aminotransferase(ALT), aspartate aminotransferase(AST), glutamine transferase(GGT), alkaline phosphatase(ALP), triglycerides(TG), total cholesterol(TC), high-density lipoprotein cholesterol(HDLC), low-density lipoprotein cholesterol(LDLC), urea nitrogen(BUN), creatinine(Cr), uric acid(UA), Central nervous system sensitivity PTFQI, TSHI, TT4RI, TFQI, Peripheral sensitivity, free thyroxine(FT), thyroid-stimulating hormone(TSH), triiodothyronine(FT), fasting blood glucose(FBG), systolic blood pressure(SBP), diastolic blood pressure(DBP), body mass index(BMI) were analyzed via binary logistic regression. Correlation between non-obese fatty liver and high blood lipids, hypertension, hyperuricemia, diabetes, thyroid dysfunction were analyzed using the Pearson and Spearman methods. ROC curve was used to evaluate the diagnostic effect of the indicator.
Compared with the normal group, age, proportion of males, ALT, AST, GGT, ALP, TG, TC, BUN, Cr, UA, TSHI, TT4RI, FT/FT, TSH, FT, FBG, SBP, DBP and BMI in the disease group were significantly higher. The prevalence of non-obese fatty liver was associated with hyperlipidemia, hypertension, hyperuricemia and diabetes. Gender, age, DBIL, ALT, ALP, TG, HDL-C, LDL-C, BUN, UA, FBG, DBP, BMI were independent risk factors for non-obese fatty liver.FT/FT may be considered as a predictor of nonobese fatty liver.
Risk factors for non-obese fatty liver may include sex, age, TG, TC, BMI, etc. Hyperlipidemia, hypertension, hyperuricemia and diabetes mellitus are related to non-obese fatty liver. FT/FT may be a predictor of non-obese fatty liver disease.
本研究旨在探讨中国人群中非肥胖型脂肪肝疾病的危险因素及预测指标。
本研究纳入了2019年3月至2023年3月在华中科技大学同济医学院附属协和医院进行体检的6014名成年人。脂肪肝疾病根据以下至少两条标准进行诊断：相对于肝脏、脾脏和肾脏的弥漫性回声模式；超声束衰减；以及肝内视觉细节不佳。通过二元逻辑回归分析非肥胖型脂肪肝与性别、年龄、总胆红素（TBIL）、直接胆红素（DBIL）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、谷氨酰胺转移酶（GGT）、碱性磷酸酶（ALP）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDLC）、低密度脂蛋白胆固醇（LDLC）、尿素氮（BUN）、肌酐（Cr）、尿酸（UA）、中枢神经系统敏感性PTFQI、TSHI、TT4RI、TFQI、外周敏感性、游离甲状腺素（FT）、促甲状腺激素（TSH）、三碘甲状腺原氨酸（FT）、空腹血糖（FBG）、收缩压（SBP）、舒张压（DBP）、体重指数（BMI）之间的关联。使用Pearson和Spearman方法分析非肥胖型脂肪肝与高血脂、高血压、高尿酸血症、糖尿病、甲状腺功能障碍之间的相关性。采用ROC曲线评估指标的诊断效果。
与正常组相比，疾病组的年龄、男性比例、ALT、AST、GGT、ALP、TG、TC、BUN、Cr、UA、TSHI、TT4RI、FT/FT、TSH、FT、FBG、SBP、DBP和BMI显著更高。非肥胖型脂肪肝的患病率与高脂血症、高血压、高尿酸血症和糖尿病有关。性别、年龄、DBIL、ALT、ALP、TG、HDL-C、LDL-C、BUN、UA、FBG、DBP、BMI是非肥胖型脂肪肝的独立危险因素。FT/FT可被视为非肥胖型脂肪肝的一个预测指标。
非肥胖型脂肪肝的危险因素可能包括性别、年龄、TG、TC、BMI等。高脂血症、高血压、高尿酸血症和糖尿病与非肥胖型脂肪肝有关。FT/FT可能是非肥胖型脂肪肝疾病的一个预测指标。
