可溶性 ST2 与急性缺血性脑卒中后认知障碍的风险：一项前瞻性观察研究。
Soluble ST2 and risk of cognitive impairment after acute ischemic stroke: a prospective observational study.
机构信息
Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, 199 Renai Road, Industrial Park District, Suzhou, 215123, Jiangsu Province, China.
Department of Epidemiology, School of Public Health, Chongqing Medical University, Chongqing, China.
出版信息
BMC Geriatr. 2021 May 24;21(1):330. doi: 10.1186/s12877-021-02288-6.
BACKGROUND
Soluble suppression of tumorigenesis-2 (sST2) was reported to be associated with cognitive performance and risk of incident stroke. However, the impact of sST2 on cognitive function after ischemic stroke is unclear. We aimed to assess the association of sST2 and cognitive impairment at 3 months in acute ischemic stroke patients.
METHODS
Baseline plasma sST2 levels were measured in 619 ischemic stroke patients (mean age: 60.0 ± 10.5 years) from 7 participating hospitals of the China Antihypertensive Trial in Acute Ischemic Stroke. Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) were used to assess cognitive status. Cognitive impairment was defined as a MoCA score < 23 or MMSE score < 27. The association between sST2 and cognitive impairment was evaluated by logistic regression analysis.
RESULTS
325 (52.5%) or 323 (52.2%) participants developed cognitive impairment according to MoCA or MMSE. After adjustment for age, sex, education, and other covariates, the odds ratio for the highest vs lowest quartile of sST2 was 2.38 (95% CI, 1.42-4.00) and 1.82 (95% CI 1.09-3.03) risk of cognitive impairment defined by MoCA and MMSE score, respectively. Incorporation sST2 into a model containing conventional risk factors significantly improved reclassification.
CONCLUSIONS
Elevated plasma sST2 levels were significantly associated with post-stroke cognitive impairment.
背景
可溶性抑瘤素 2（sST2）与认知表现和中风风险相关。然而，sST2 对缺血性中风后认知功能的影响尚不清楚。我们旨在评估急性缺血性中风患者中 sST2 与 3 个月时认知障碍的相关性。
方法
在来自 7 家参与医院的 619 名缺血性中风患者（平均年龄：60.0±10.5 岁）中测量了基线血浆 sST2 水平。使用蒙特利尔认知评估（MoCA）和简易精神状态检查（MMSE）评估认知状态。认知障碍定义为 MoCA 评分<23 或 MMSE 评分<27。通过逻辑回归分析评估 sST2 与认知障碍之间的关系。
结果
根据 MoCA 或 MMSE，325（52.5%）或 323（52.2%）名患者发生认知障碍。调整年龄、性别、教育程度和其他协变量后，sST2 最高四分位数与最低四分位数相比，MoCA 评分和 MMSE 评分定义的认知障碍的优势比分别为 2.38（95%CI，1.42-4.00）和 1.82（95%CI，1.09-3.03）。将 sST2 纳入包含传统危险因素的模型中显著提高了重新分类。
结论
血浆 sST2 水平升高与中风后认知障碍显著相关。
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