Mohammadi Seyed Mohammad, Saniee Nadia, Mousaviasl Sajedeh, Radmanesh Esmat, Doustimotlagh Amir Hossein
Department of Orthopedics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Basic Science, Asadabad School of Medical Sciences, Asadabad, Iran.
Iran J Public Health. 2024 Nov;53(11):2432-2439. doi: 10.18502/ijph.v53i11.16945.
Osteoporosis is the most common systemic skeletal disease worldwide. We aimed to review the latest studies related to osteocalcin and osteoporosis to clarify this relationship more precisely.
A systematic literature search was performed to review studies on the effects of osteocalcin on osteoporosis, on studied published between January 2013 and January 2023. We systematically reviewed Web of Science, PubMed, ProQuest, Scopus, and Google Scholar.
The search yielded 4903 records, including 1063 from PubMed, 2307 from Scopus, 1084 from Web of Science, 408 from ProQuest, and 41 from Google Scholar, and twelve articles were included for data extraction and quality assessment. A significant increase in the serum level of osteocalcin was observed in postmenopausal women with osteoporosis (<0.05), and there was a negative correlation between bone mineral density and the serum level of osteocalcin.
Osteocalcin could be a promising marker for the diagnosis and screening of patients with osteoporosis.
骨质疏松症是全球最常见的全身性骨骼疾病。我们旨在回顾与骨钙素和骨质疏松症相关的最新研究，以更准确地阐明这种关系。
进行了系统的文献检索，以回顾2013年1月至2023年1月期间发表的关于骨钙素对骨质疏松症影响的研究。我们系统地检索了科学网、PubMed、ProQuest、Scopus和谷歌学术。
检索得到4903条记录，其中来自PubMed的有1063条，来自Scopus的有2307条，来自科学网的有1084条，来自ProQuest的有408条，来自谷歌学术的有41条，纳入12篇文章进行数据提取和质量评估。在患有骨质疏松症的绝经后女性中观察到骨钙素血清水平显著升高（<0.05），并且骨密度与骨钙素血清水平之间存在负相关。
骨钙素可能是诊断和筛查骨质疏松症患者的一个有前景的标志物。
