Parvaneh Jahan, Namazi Fatemeh, Razavi Seyed Mostafa, Nazifi Saeed, Nayebzadeh Hassan
Department of Pathobiology, School of Veterinary Medicine Shiraz University Shiraz Iran.
Department of Clinical Studies, School of Veterinary Medicine Shiraz University Shiraz Iran.
Food Sci Nutr. 2024 Oct 23;12(11):9727-9734. doi: 10.1002/fsn3.4515. eCollection 2024 Nov.
is a protozoan parasite that infects approximately one billion people worldwide. In this study, the effects of lycopene on experimental giardiasis in mice were investigated by evaluating cyst shedding rate, weight changes, duodenal antioxidant status, and histopathological alteration. Ninety-five male mice aged four to six weeks were divided into six groups of 15 and one group of 5 as the negative control. All mice were infected with 2 × 10 (B genotype) cysts except for the negative control. The treatment groups were treated with metronidazole, mixed lycopene-metronidazole, and 5, 10, and 20 mg/kg lycopene for 7 days. The mice treated with lycopene 20 and mixed lycopene-metronidazole had no cyst shedding from the 7 day of treatment. The mildest lesions were observed in the mixed lycopene-metronidazole group. Results showed that treatment with mixed lycopene-metronidazole significantly increased TAC and decreased MDA levels as compared with the positive control. It seems that the antigiardial effect of lycopene is related to its antioxidant properties. Nevertheless, direct effect of lycopene on and its probable mechanism remain to be investigated.
是一种原生动物寄生虫，全球约有10亿人受其感染。在本研究中，通过评估囊肿排出率、体重变化、十二指肠抗氧化状态和组织病理学改变，研究了番茄红素对小鼠实验性贾第虫病的影响。将95只4至6周龄的雄性小鼠分为6组，每组15只，另有一组5只作为阴性对照。除阴性对照外，所有小鼠均感染2×10 （B基因型）囊肿。治疗组分别用甲硝唑、番茄红素-甲硝唑混合物以及5、10和20mg/kg番茄红素治疗7天。用20mg/kg番茄红素和番茄红素-甲硝唑混合物治疗的小鼠从治疗第7天起不再有囊肿排出。在番茄红素-甲硝唑混合物组中观察到的病变最轻。结果表明，与阳性对照相比，番茄红素-甲硝唑混合物治疗显著提高了总抗氧化能力（TAC）并降低了丙二醛（MDA）水平。番茄红素的抗贾第虫作用似乎与其抗氧化特性有关。然而，番茄红素对 的直接作用及其可能的机制仍有待研究。
