Quan Shaohao, Yang Jie, Huang Sirui, Shao Jundong, Liu Yang, Yang Hui
School of Medical Information Engineering, Gannan Medical University, Ganzhou 341000, China.
School of Rehabilitation Medicine, Gannan Medical University, Ganzhou 341000, China.
Biomater Sci. 2025 Jan 14;13(2):364-378. doi: 10.1039/d4bm00950a.
Silk fibroin (SF), a pivotal biomaterial, holds immense promise for diverse applications within the realm of bone tissue engineering. SF is an ideal scaffold material with exceptional biocompatibility, mechanical robustness, biodegradability, and bioactivity. A plethora of investigations have corroborated SF's efficacy in supporting bone tissue repair and regeneration. This comprehensive review delves into the structural attributes, physicochemical characteristics, and extraction methodologies of SF. Moreover, it elucidates the strides taken in harnessing SF across a spectrum of forms, including films, hydrogels, scaffolds, electrospun fibers, and composites for bone tissue engineering applications. Moreover, the application bottleneck of SF as a bone repair material is highlighted, and its development prospects and potential biomedical applications are also presented in this review. We expect that this review can inspire the broad interest of a wide range of readers working in the fields of materials science, tissue engineering, biomaterials, bioengineering, and biomedicine.
丝素蛋白（SF）是一种关键的生物材料，在骨组织工程领域的多种应用中具有巨大潜力。SF是一种理想的支架材料，具有卓越的生物相容性、机械强度、生物降解性和生物活性。大量研究证实了SF在支持骨组织修复和再生方面的功效。这篇综述深入探讨了SF的结构特性、物理化学特征和提取方法。此外，还阐述了在骨组织工程应用中利用SF的各种形式（包括薄膜、水凝胶、支架、电纺纤维和复合材料）所取得的进展。此外，本综述还强调了SF作为骨修复材料的应用瓶颈，并介绍了其发展前景和潜在的生物医学应用。我们期望这篇综述能够激发材料科学、组织工程、生物材料、生物工程和生物医学领域广大读者的广泛兴趣。
