Department of BIN Convergence Technology, Chonbuk National University, Jeonju-si, Jeollabuk-do, South Korea.
Department of PolymerNano Science & Technology and Polymer Fusion Research Center, Chonbuk National University, Jeonju-si, Jeollabuk-do, South Korea.
Adv Exp Med Biol. 2018;1077:371-387. doi: 10.1007/978-981-13-0947-2_20.
Regeneration of diseased or damaged skeletal tissues is one of the challenge that needs to be solved. Although there have been many bone tissue engineering developed, scaffold-based tissue engineering complement the conventional treatment for large bone by completing biological and functional environment. Among many materials, silk fibroin (SF) is one of the favorable material for applications in bone tissue engineering scaffolding. SF is a fibrous protein mainly extracted from Bombyx mori. and spiders. SF has been used as a biomaterial for bone graft by its unique mechanical properties, controllable biodegradation rate and high biocompatibility. Moreover, SF can be processed using conventional and advanced biofabrication methods to form various scaffold types such as sponges, mats, hydrogels and films. This review discusses about recent application and advancement of SF as a biomaterial.
再生病变或受损的骨骼组织是需要解决的挑战之一。尽管已经开发出许多骨组织工程技术，但基于支架的组织工程通过完成生物和功能环境来补充传统的大骨治疗方法。在许多材料中，丝素蛋白（SF）是一种在骨组织工程支架中应用的理想材料。SF 是一种纤维状蛋白质，主要从家蚕和蜘蛛中提取。SF 因其独特的机械性能、可控的生物降解率和高生物相容性而被用作骨移植物的生物材料。此外，SF 可以使用传统和先进的生物制造方法进行加工，以形成各种支架类型，如海绵、垫、水凝胶和薄膜。本文综述了 SF 作为生物材料的最新应用和进展。
