Li Zhanhong, Li Peihui, Xu Yu, Yan Changqing, Ma Xiufen, Wang Huiying, Cheng Hong, Zeng Jing, Li Ting, Li Xinxian, Zhou Jia, Zhang Jie, Zhou Jianfeng, Yang Rongya, Wu Yan, Li Li, Lai Wei, Zhao Jiangyun, Liu Zhe, Meng Qiong
Guangzhou MLT Medical Cosmetic Clinic, Guangzhou, China.
Changsha 7HE VLINES Medical Cosmetic Hospital, Changsha, China.
J Cosmet Dermatol. 2025 Feb;24(2):e16703. doi: 10.1111/jocd.16703. Epub 2024 Dec 2.
Acne vulgaris significantly affects young individuals globally, with its onset associated with an increased prevalence of C acnes, a naturally occurring skin bacterium. In light of the rising concerns regarding antibiotic resistance and the potential for adverse effects, pharmacological interventions may not consistently represent the most suitable option. Nonpharmacological approaches, such as microneedling, offer promising alternative treatment modalities. Furthermore, the integration of postbiotics in skincare formulations for acne management has gained traction recently. Nonetheless, there remains a lack of sufficient evidence to establish the efficacy and safety of postbiotics when combined with microneedling.
To assess the clinical effectiveness of a postbiotic formulation combined with microneedling in mild-to-moderate facial acne vulgaris.
Twenty Chinese patients were enrolled, all received one treatment and were monitored 4 weeks posttreatment. The evaluation assessed symptom improvement, treatment safety, and patient satisfaction.
The global acne grading system (GAGS) score decreased more than half based on the baseline. Clinical photographs following treatment revealed improved the skin lesions and brightened skin tone. Statistics from VISIA showed excellent improvement in speckle, pore, red region, and porphyrin. No significant adverse reactions have been reported during the treatment period. Additionally, more than 85% were very satisfied or satisfied with the outcome.
Our results showed that the postbiotic formulation combined with microneedling may benefit the restoration of the skin barrier and the equilibrium of skin microbiota. This approach may help mitigate inflammation and address skin lesions, presenting a promising therapeutic avenue for the prevention and management of acne vulgaris.
寻常痤疮在全球范围内对年轻人有显著影响，其发病与痤疮丙酸杆菌（一种天然存在的皮肤细菌）的患病率增加有关。鉴于对抗生素耐药性的担忧日益增加以及潜在的不良反应，药物干预可能并不总是最合适的选择。非药物方法，如微针疗法，提供了有前景的替代治疗方式。此外，后生元在痤疮管理护肤配方中的整合最近受到了关注。然而，仍然缺乏足够的证据来确定后生元与微针疗法联合使用时的疗效和安全性。
评估后生元配方联合微针疗法治疗轻至中度面部寻常痤疮的临床效果。
招募了20名中国患者，所有患者均接受了一次治疗，并在治疗后4周进行监测。评估包括症状改善、治疗安全性和患者满意度。
基于基线，全球痤疮分级系统（GAGS）评分下降超过一半。治疗后的临床照片显示皮肤病变有所改善，肤色变亮。VISIA的统计数据显示，在色斑、毛孔、红色区域和卟啉方面有显著改善。治疗期间未报告明显的不良反应。此外，超过85%的患者对治疗结果非常满意或满意。
我们的结果表明，后生元配方联合微针疗法可能有利于皮肤屏障的恢复和皮肤微生物群的平衡。这种方法可能有助于减轻炎症和解决皮肤病变，为寻常痤疮的预防和管理提供了一条有前景的治疗途径。
