Division of Biochemistry, ICAR-NDRI, 132001, India.
Animal Biotechnology Center, ICAR-NDRI, 132001, India.
Food Funct. 2023 May 11;14(9):3966-3981. doi: 10.1039/d3fo00152k.
Probiotics and postbiotics have emerged as an alternative to traditional antibiotics for the treatment of persistent skin infections. The use of probiotics and postbiotics has been shown to have a positive impact on the maintenance of skin health by promoting the growth of beneficial bacteria and inhibiting the growth of harmful bacteria. Probiotics work by adhering to the skin and mucosal membranes and competing with pathogenic organisms for nutrients, which prevent the growth of harmful bacteria. In addition, probiotics and postbiotics produce antimicrobial substances that help eliminate pathogenic bacteria, resulting in improved skin health. The skin is the largest organ in the body and serves as a protective barrier against external pathogens. When harmful bacteria colonize the skin, it can lead to tissue damage and disruption, which can cause chronic inflammatory, non-healing skin disorders such as dermatitis, psoriasis, and acne. Traditional treatments for persistent skin infections rely heavily on antibiotics, which can have several adverse effects on the body, including the development of antibiotic resistance. Moreover, pathogens such as and , which are often implicated in chronic skin infections, can form biofilms that are highly resistant to antibiotics and host immune responses. In recent years, research has shown that probiotics and postbiotics can play a significant role in the maintenance of dermal health. Probiotics and postbiotics can stimulate the immune system, enhance the production of skin barrier components, and modulate skin inflammation, all of which are critical for the maintenance of healthy skin. In this review, we have compiled the current literature on the therapeutic potential of probiotics and postbiotics for the treatment of persistent skin infections and their impact on maintaining dermal health.
益生菌和后生元已成为治疗持续性皮肤感染的传统抗生素的替代品。益生菌和后生元的使用已被证明对维持皮肤健康具有积极影响,通过促进有益细菌的生长和抑制有害细菌的生长来实现。益生菌通过黏附在皮肤和黏膜上,并与病原体争夺营养物质来发挥作用,从而阻止有害细菌的生长。此外,益生菌和后生元会产生抗菌物质,有助于消除病原体,从而改善皮肤健康。皮肤是人体最大的器官,是抵御外部病原体的保护屏障。当有害细菌在皮肤上定植时,会导致组织损伤和破坏,从而引发慢性炎症性、非愈合性皮肤疾病,如皮炎、银屑病和痤疮。持续性皮肤感染的传统治疗方法主要依赖抗生素,但抗生素会对身体产生多种不良反应,包括抗生素耐药性的产生。此外, 和 等病原体通常与慢性皮肤感染有关,它们可以形成对抗生素和宿主免疫反应具有高度抵抗力的生物膜。近年来,研究表明,益生菌和后生元在维持皮肤健康方面可以发挥重要作用。益生菌和后生元可以刺激免疫系统、增强皮肤屏障成分的产生并调节皮肤炎症,所有这些都是维持健康皮肤的关键。在这篇综述中,我们汇总了关于益生菌和后生元治疗持续性皮肤感染的治疗潜力及其对维持皮肤健康影响的现有文献。