Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Curr Opin Microbiol. 2023 Aug;74:102311. doi: 10.1016/j.mib.2023.102311. Epub 2023 Apr 4.
The skin is a pivotal barrier between the human body and the environment, and is a habitat for numerous microorganisms. While host-microbiota interactions in the skin are essential for homeostasis, disturbances in microbial composition and the abnormal growth of certain bacteria are associated with various diseases. Here, we identify strains and communities of skin commensals that contribute to or impair skin barrier function. Furthermore, we discuss the skin microenvironments suitable for specific microbiota that exert therapeutic effects and suggest focus areas for the prospective development of therapeutic strategies using bacterial agents. Finally, we highlight recent efforts to treat skin diseases associated with live bacteria.
皮肤是人体与环境之间的关键屏障，也是众多微生物的栖息地。虽然皮肤中的宿主-微生物相互作用对维持内环境稳定至关重要，但微生物组成的紊乱和某些细菌的异常生长与各种疾病有关。在这里，我们鉴定了有助于或损害皮肤屏障功能的皮肤共生菌菌株和群落。此外，我们还讨论了适合发挥治疗效果的特定微生物群的皮肤微环境，并提出了利用细菌制剂开发治疗策略的重点领域。最后，我们强调了最近在利用活菌治疗与皮肤相关疾病方面的努力。
