Sheinberg Waisburd Galia, Romero Núñez Camilo, Martin Cordero Alberto, Heredia Cárdenas Rafael, Flores Ortega Ariadna
Dermatologia Especializada, Centro Veterinario México, Ciudad de México, México.
Dermavet Hospital Veterinario, José de la Luz Blanco, Ciudad de México, México.
Vet Med Sci. 2025 Jan;11(1):e70075. doi: 10.1002/vms3.70075.
Canine superficial pyoderma (CSP) is common. Antibiotic and potential antiseptic resistance is a rising concern; natural topicals may provide valuable alternative options.
Compare natural topicals containing essential oils, plant-extracted essential fatty acids and N-acetylcysteine to a medicated shampoo with chlorhexidine, miconazole and micronized silver in treating CSP.
Thirty dogs diagnosed with CSP, divided into three groups as outlined below.
Group 1 bathed using a shampoo (PYOclean Shampoo) twice weekly and application of a rinse-free mousse (PYOclean Mousse) once daily, Group 2 bathed using the same shampoo as above twice weekly and application of a spray (PYOclean Spray) once daily, and Group 3 bathed using a medicated shampoo (Biohex Shampoo) twice weekly.
Cytology, lesion and pruritus visual analogue (PVAS) scores were evaluated on Days (D) 0, 7 and 15.
All three groups showed decreased polymorphonuclear cells (PMN) on D15. The reduction was significant, and more significant in Groups 1 and 2 (90.48% and 98.93%) compared to Group 3 (85.96%); extracellular cocci (cocci EC) significantly decreased by 92.8% and 93.38% in Groups 1 and 2, whereas decreased by 81% in Group 3 on D15. The number of yeasts on D15 decreased by 90% in Group 3 and 82% and 92%, respectively, in Groups 1 and 2. Lesion scores decreased on D15 by 90.61% and 87.95% in Groups 1 and 2 and by 62.94% in Group 3. PVAS decreased on D15 by 95.78% and 96.75%, respectively, in Groups 1 and 2 and by 69.88% in Group 3.
Efficacy of three natural topicals in treating dogs with superficial pyoderma without adding any systemic antimicrobial drugs was demonstrated. Such solutions can be complementary to medications such as chlorhexidine and miconazole in addressing CSP.
犬浅表脓皮病（CSP）很常见。抗生素和潜在的防腐剂耐药性问题日益受到关注；天然外用药物可能提供有价值的替代选择。
比较含有精油、植物提取的必需脂肪酸和N - 乙酰半胱氨酸的天然外用药物与含有洗必泰、咪康唑和微粉化银的药用洗发水在治疗CSP方面的效果。
30只被诊断为CSP的犬，分为如下三组。
第1组每周使用洗发水（PYOclean洗发水）洗澡两次，每天使用免冲洗慕斯（PYOclean慕斯）一次；第2组每周使用与上述相同的洗发水洗澡两次，每天使用喷雾（PYOclean喷雾）一次；第3组每周使用药用洗发水（Biohex洗发水）洗澡两次。
在第0天、第7天和第15天评估细胞学、病变和瘙痒视觉模拟（PVAS）评分。
所有三组在第15天多形核细胞（PMN）数量均减少。减少幅度显著，第1组和第2组（分别为90.48%和98.93%）比第3组（85.96%）更显著；第15天，第1组和第2组细胞外球菌（球菌EC）数量显著减少92.8%和93.38%，而第3组减少81%。第15天，第3组酵母菌数量减少90%，第1组和第2组分别减少82%和92%。第15天，第1组和第2组病变评分分别降低90.61%和87.95%，第3组降低62.94%。第15天，第1组和第2组PVAS分别降低95.78%和96.75%，第3组降低69.88%。
证明了三种天然外用药物在不添加任何全身抗菌药物的情况下治疗犬浅表脓皮病的有效性。这些解决方案在治疗CSP方面可作为洗必泰和咪康唑等药物的补充。
