Yuan Yue, Zhao Gang, Zhao Yang
Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin, 130061, China.
China Resources Pharmaceutical Commercial Group, Beijing, China.
J Neurol. 2024 Dec 2;272(1):2. doi: 10.1007/s00415-024-12800-8.
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. Its etiology and associated mechanisms are still unclear, which largely hinders the development of AD treatment strategies. Many studies have shown that dysregulation of energy metabolism in the brain of AD is closely related to disease development. Dysregulation of brain energy metabolism in AD brain is associated with reduced glucose uptake and utilization, altered insulin signaling pathways, and mitochondrial dysfunction. In this study, we summarized the relevant pathways and mechanisms regarding the dysregulation of energy metabolism in AD. In addition, we highlight the possible role of mitochondrial dysfunction as a central role in the AD process. A deeper understanding of the relationship between energy metabolism dysregulation and AD may provide new insights for understanding learning memory impairment in AD patients and in improving AD prevention and treatment.
阿尔茨海默病（AD）是最常见的神经退行性疾病之一。其病因及相关机制仍不清楚，这在很大程度上阻碍了AD治疗策略的发展。许多研究表明，AD患者大脑中的能量代谢失调与疾病发展密切相关。AD大脑中的能量代谢失调与葡萄糖摄取和利用减少、胰岛素信号通路改变以及线粒体功能障碍有关。在本研究中，我们总结了AD中能量代谢失调的相关途径和机制。此外，我们强调了线粒体功能障碍在AD进程中可能扮演的核心角色。更深入地了解能量代谢失调与AD之间的关系，可能为理解AD患者的学习记忆障碍以及改善AD的预防和治疗提供新的见解。
