Bonfim Camila, Alves Flávia, Fialho Érika, Naslund John A, Barreto Maurício L, Patel Vikram, Machado Daiane Borges
Centre of Data and Knowledge Integration for Health (CIDACS), Fiocruz-Bahia, Salvador, Bahia, Brazil.
Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
PLoS Med. 2024 Dec 2;21(12):e1004486. doi: 10.1371/journal.pmed.1004486. eCollection 2024 Dec.
Psychiatric patients experience lower life expectancy compared to the general population. Conditional cash transfer programmes (CCTPs) have shown promise in reducing mortality rates, but their impact on psychiatric patients has been unclear. This study tests the association between being a Brazilian Bolsa Família Programme (BFP) recipient and the risk of mortality among people previously hospitalised with any psychiatric disorders.
This cohort study utilised Brazilian administrative datasets, linking social and health system data from the 100 Million Brazilian Cohort, a population-representative study. We followed individuals who applied for BFP following a single hospitalisation with a psychiatric disorder between 2008 and 2015. The outcome was mortality and specific causes, defined according to International Classification of Diseases 10th Revision (ICD-10). Cox proportional hazards models estimated the hazard ratio (HR) for overall mortality and competing risks models estimated the HR for specific causes of death, both associated with being a BFP recipient, adjusted for confounders, and weighted with a propensity score. We included 69,901 psychiatric patients aged between 10 and 120, with the majority being male (60.5%), and 26,556 (37.99%) received BFP following hospitalisation. BFP was associated with reduced overall mortality (HR 0.93, 95% CI 0.87,0.98, p 0.018) and mortality due to natural causes (HR 0.89, 95% CI 0.83, 0.96, p < 0.001). Reduction in suicide (HR 0.90, 95% CI 0.68, 1.21, p = 0.514) was observed, although it was not statistically significant. The BFP's effects on overall mortality were more pronounced in females and younger individuals. In addition, 4% of deaths could have been prevented if BFP had been present (population attributable risk (PAF) = 4%, 95% CI 0.06, 7.10).
BFP appears to reduce mortality rates among psychiatric patients. While not designed to address elevated mortality risk in this population, this study highlights the potential for poverty alleviation programmes to mitigate mortality rates in one of the highest-risk population subgroups.
与普通人群相比,精神疾病患者的预期寿命较低。有条件现金转移支付计划(CCTPs)在降低死亡率方面已显示出前景,但其对精神疾病患者的影响尚不清楚。本研究检验了巴西家庭补助金计划(BFP)受助者与既往因任何精神疾病住院的人群的死亡风险之间的关联。
这项队列研究利用了巴西行政数据集,将来自具有人口代表性的“1亿巴西队列”的社会和卫生系统数据相链接。我们追踪了2008年至2015年间因精神疾病单次住院后申请BFP的个体。结局为死亡率及特定死因,根据国际疾病分类第10版(ICD - 10)进行定义。Cox比例风险模型估计了总体死亡率的风险比(HR),竞争风险模型估计了特定死因的HR,二者均与BFP受助情况相关,对混杂因素进行了调整,并使用倾向得分进行加权。我们纳入了69901名年龄在10至120岁之间的精神疾病患者,其中大多数为男性(60.5%),26556名(37.99%)在住院后接受了BFP。BFP与总体死亡率降低相关(HR 0.93,95%CI 0.87,0.98,p = 0.018)以及自然原因导致的死亡率降低相关(HR 0.89,95%CI 0.83,0.96,p < 0.001)。虽观察到自杀率有所降低(HR 0.90,95%CI 0.68,1.21,p = 0.514),但无统计学意义。BFP对总体死亡率的影响在女性和年轻个体中更为显著。此外,如果实施BFP,4%的死亡本可避免(人群归因风险(PAF)= 4%,95%CI 0.06,7.10)。
BFP似乎可降低精神疾病患者的死亡率。虽然该计划并非旨在解决这一人群中升高的死亡风险,但本研究凸显了扶贫计划在降低这一最高风险人群亚组之一的死亡率方面的潜力。