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Genetic recording of transient endothelial activation in distinct alveolar capillary cells during pulmonary fibrosis.

作者信息

Li Hongxin, Zhang Shaohua, Huang Xiuzhen, Zhang Zhenqian, Liu Kuo, Wang Qing-Dong, Chen Alex F, Lui Kathy O, Sun Kun, Zhou Bin

机构信息

CAS CEMCS-CUHK Joint Laboratories for Cardiovascular Sciences, New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang, China.

出版信息

Cell Discov. 2024 Dec 3;10(1):119. doi: 10.1038/s41421-024-00745-1.

DOI:10.1038/s41421-024-00745-1
PMID:39622809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11612399/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f0/11612399/e54c4b079752/41421_2024_745_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f0/11612399/e54c4b079752/41421_2024_745_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d2f0/11612399/e54c4b079752/41421_2024_745_Fig1_HTML.jpg

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Generation of Plvap-CreER and Car4-CreER for genetic targeting of distinct lung capillary populations.生成用于不同肺毛细血管群体基因靶向的Plvap-CreER和Car4-CreER。
J Genet Genomics. 2022 Dec;49(12):1093-1100. doi: 10.1016/j.jgg.2022.08.001. Epub 2022 Aug 23.
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Pathogenic Mechanisms Underlying Idiopathic Pulmonary Fibrosis.特发性肺纤维化的发病机制。
Annu Rev Pathol. 2022 Jan 24;17:515-546. doi: 10.1146/annurev-pathol-042320-030240. Epub 2021 Nov 23.
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Seamless Genetic Recording of Transiently Activated Mesenchymal Gene Expression in Endothelial Cells During Cardiac Fibrosis.心脏纤维化过程中内皮细胞中转录激活的间充质基因表达的无缝遗传记录。
Circulation. 2021 Dec 21;144(25):2004-2020. doi: 10.1161/CIRCULATIONAHA.121.055417. Epub 2021 Nov 19.
5
Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension.单细胞 RNA 测序分析肺动脉高压小鼠血管内皮细胞的反应。
Cardiovasc Res. 2022 Aug 24;118(11):2519-2534. doi: 10.1093/cvr/cvab296.
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Capillary cell-type specialization in the alveolus.肺泡毛细血管细胞类型特化。
Nature. 2020 Oct;586(7831):785-789. doi: 10.1038/s41586-020-2822-7. Epub 2020 Oct 14.
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