Kim Min Seok, Lee Eun Ji, Lee Si Un, Kim Tae-Woo, Park Sang Jun, Woo Se Joon, Lee Jeongwoo, Nam Seonghee, Joo Kwangsic
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Sci Rep. 2024 Dec 2;14(1):29992. doi: 10.1038/s41598-024-80491-2.
This nationwide population-based retrospective cohort study aims to investigate the association between Moyamoya disease (MMD) and open-angle glaucoma (OAG). In this study using the Korean National Health Insurance Service database, a total of 36,432 patients having diagnostic code with MMD between 2002 and 2022, and their age-, sex-matched non-MMD controls (n = 346,769) were included. We used a Cox proportional hazard model to determine the association between MMD and subsequent OAG after excluding cases with preexisting diagnosis of MMD for the initial 2-year. Kaplan-Meier survival analyses with log-rank test were performed to compare the incidence probability of OAG based on the MMD diagnosis. Cox regression analysis showed that the diagnosis of MMD was associated with increased risk of subsequent diagnosis of OAG (adjusted HR, 1.26; 95% CI, 1.14-1.38; P < 0.001). The cumulative incidence probability of OAG was 3.7% in MMD group and 2.9% in control group at the end of the study period, and was significantly higher among MMD patients than controls consistently during the study period (P < 0.001).In conclusion, the nationwide longitudinal data of Korean population revealed a significant association between MMD and OAG. Presence of MMD may increase the risk of developing OAG.
这项基于全国人口的回顾性队列研究旨在调查烟雾病（MMD）与开角型青光眼（OAG）之间的关联。在这项使用韩国国民健康保险服务数据库的研究中，纳入了2002年至2022年间共有36432例有MMD诊断代码的患者，以及年龄和性别匹配的非MMD对照组（n = 346769）。在排除最初2年已有MMD诊断的病例后，我们使用Cox比例风险模型来确定MMD与随后发生OAG之间的关联。进行了Kaplan-Meier生存分析和对数秩检验，以比较基于MMD诊断的OAG发病概率。Cox回归分析表明，MMD诊断与随后诊断为OAG的风险增加相关（调整后的HR，1.26；95%CI，1.14 - 1.38；P < 0.001）。在研究期结束时，MMD组中OAG的累积发病概率为3.7%，对照组为2.9%，并且在研究期间MMD患者中的累积发病概率始终显著高于对照组（P < 0.001）。总之，韩国人群的全国纵向数据显示MMD与OAG之间存在显著关联。MMD的存在可能会增加患OAG的风险。
